| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent histone deacetylase SIR2 |
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| Ligand | BDBM50146061 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_202251 |
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| IC50 | 86000±n/a nM |
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| Citation |  Posakony, J; Hirao, M; Stevens, S; Simon, JA; Bedalov, A Inhibitors of Sir2: evaluation of splitomicin analogues. J Med Chem47:2635-44 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| NAD-dependent histone deacetylase SIR2 |
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| Name: | NAD-dependent histone deacetylase SIR2 |
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| Synonyms: | MAR1 | SIR2 | SIR2_YEAST |
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| Type: | PROTEIN |
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| Mol. Mass.: | 63277.80 |
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| Organism: | Saccharomyces cerevisiae |
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| Description: | ChEMBL_942450 |
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| Residue: | 562 |
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| Sequence: | MTIPHMKYAVSKTSENKVSNTVSPTQDKDAIRKQPDDIINNDEPSHKKIKVAQPDSLRET
NTTDPLGHTKAALGEVASMELKPTNDMDPLAVSAASVVSMSNDVLKPETPKGPIIISKNP
SNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQAL
IGTINSIVHINSQERVQDLGSAISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRLRLSN
FFTIDHFIQKLHTARKILVLTGAGVSTSLGIPDFRSSEGFYSKIKHLGLDDPQDVFNYNI
FMHDPSVFYNIANMVLPPEKIYSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKL
VQCHGSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRREYFPEGYNNKVGVAAS
QGSMSERPPYILNSYGVLKPDITFFGEALPNKFHKSIREDILECDLLICIGTSLKVAPVS
EIVNMVPSHVPQVLINRDPVKHAEFDLSLLGYCDDIAAMVAQKCGWTIPHKKWNDLKNKN
FKCQEKDKGVYVVTSDEHPKTL
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| BDBM50146061 |
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| n/a |
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| Name | BDBM50146061 |
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| Synonyms: | CHEMBL89585 | {2-[2-(3-Oxo-2,3-dihydro-1H-benzo[f]chromen-5-yloxy)-ethoxy]-ethyl}-carbamic acid tert-butyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27NO6 |
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| Mol. Mass. | 401.4529 |
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| SMILES | CC(C)(C)OC(=O)NCCOCCOc1cc2ccccc2c2CCC(=O)Oc12 |
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| Structure | 
|
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