| Reaction Details |
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 | Report a problem with these data |
| Target | Vasopressin V2 receptor |
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| Ligand | BDBM50146577 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_215032 |
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| IC50 | 0.200000±n/a nM |
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| Citation |  Xiang, MA; Chen, RH; Demarest, KT; Gunnet, J; Look, R; Hageman, W; Murray, WV; Combs, DW; Patel, M Synthesis and evaluation of spirobenzazepines as potent vasopressin receptor antagonists. Bioorg Med Chem Lett14:2987-9 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vasopressin V2 receptor |
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| Name: | Vasopressin V2 receptor |
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| Synonyms: | ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor |
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| Type: | Receptor |
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| Mol. Mass.: | 40295.28 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30518 |
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| Residue: | 371 |
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| Sequence: | MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLA
ALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQM
VGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQ
RNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGP
SERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEA
PLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTT
ASSSLAKDTSS
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| BDBM50146577 |
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| n/a |
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| Name | BDBM50146577 |
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| Synonyms: | CHEMBL102311 | spirobenzoxazines analogues |
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| Type | Small organic molecule |
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| Emp. Form. | C30H30N2O3 |
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| Mol. Mass. | 466.5708 |
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| SMILES | COc1ccccc1C(=O)Nc1ccc(cc1)C(=O)N1CCC2(CCCC=C2)Cc2ccccc12 |c:28| |
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| Structure | 
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