Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM50146641 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_157738 (CHEMBL765176) |
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Ki | 42±n/a nM |
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Citation | Pierce, AC; Rao, G; Bemis, GW BREED: Generating novel inhibitors through hybridization of known ligands. Application to CDK2, p38, and HIV protease. J Med Chem47:2768-75 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50146641 |
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n/a |
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Name | BDBM50146641 |
Synonyms: | CHEMBL96348 | {(S)-1-(R)-1-Benzyl-3-[(N-tert-Butylsulfonyl)-isobutyl-amino]-2-hydroxy-propyl}-carbamic acid (S)-(tetrahydro-furan-3-yl) ester |
Type | Small organic molecule |
Emp. Form. | C23H39N3O6S |
Mol. Mass. | 485.637 |
SMILES | CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)S(=O)(=O)NC(C)(C)C |
Structure |
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