| Reaction Details |
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 | Report a problem with these data |
| Target | Neuromedin-B receptor |
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| Ligand | BDBM50147029 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_143203 |
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| IC50 | 1850±n/a nM |
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| Citation |  Shuttleworth, SJ; Lizarzaburu, ME; Chai, A; Coward, P Identification and optimization of novel partial agonists of neuromedin B receptor using parallel synthesis. Bioorg Med Chem Lett14:3037-42 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuromedin-B receptor |
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| Name: | Neuromedin-B receptor |
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| Synonyms: | Bombesin 1 | NMB-R | NMBR | NMBR_HUMAN | Neuromedin B | Neuromedin B receptor | Neuromedin-B receptor | Neuromedin-B-preferring bombesin receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 43447.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Bombesin 1 NMBR 0::P28336 |
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| Residue: | 390 |
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| Sequence: | MPSKSLSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLG
NIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIP
VIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGIWVVSVLLAVPEAV
FSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLI
KSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSL
GHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLLSSSAV
RMTSLKSNAKNMVTNSVLLNGHSMKQEMAL
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| BDBM50147029 |
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| n/a |
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| Name | BDBM50147029 |
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| Synonyms: | 5-(3-{3-[(1-Pyridin-2-yl-cyclohexylmethyl)-carbamoyl]-2,3,4,9-tetrahydro-1H-carbazol-3-yl}-ureido)-isophthalic acid diethyl ester | CHEMBL105069 |
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| Type | Small organic molecule |
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| Emp. Form. | C38H43N5O6 |
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| Mol. Mass. | 665.7779 |
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| SMILES | CCOC(=O)c1cc(NC(=O)NC2(CCc3[nH]c4ccccc4c3C2)C(=O)NCC2(CCCCC2)c2ccccn2)cc(c1)C(=O)OCC |
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| Structure | 
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