| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuromedin-B receptor |
|---|
| Ligand | BDBM50147041 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_143203 |
|---|
| IC50 | 1110±n/a nM |
|---|
| Citation |  Shuttleworth, SJ; Lizarzaburu, ME; Chai, A; Coward, P Identification and optimization of novel partial agonists of neuromedin B receptor using parallel synthesis. Bioorg Med Chem Lett14:3037-42 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuromedin-B receptor |
|---|
| Name: | Neuromedin-B receptor |
|---|
| Synonyms: | Bombesin 1 | NMB-R | NMBR | NMBR_HUMAN | Neuromedin B | Neuromedin B receptor | Neuromedin-B receptor | Neuromedin-B-preferring bombesin receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 43447.11 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Bombesin 1 NMBR 0::P28336 |
|---|
| Residue: | 390 |
|---|
| Sequence: | MPSKSLSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLG
NIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIP
VIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGIWVVSVLLAVPEAV
FSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLI
KSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSL
GHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLLSSSAV
RMTSLKSNAKNMVTNSVLLNGHSMKQEMAL
|
|
|
|---|
| BDBM50147041 |
|---|
| n/a |
|---|
| Name | BDBM50147041 |
|---|
| Synonyms: | 3-[3-(4-Trifluoromethyl-phenyl)-ureido]-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (1-pyridin-2-yl-cyclohexylmethyl)-amide | CHEMBL105068 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C33H34F3N5O2 |
|---|
| Mol. Mass. | 589.6506 |
|---|
| SMILES | FC(F)(F)c1ccc(NC(=O)NC2(CCc3[nH]c4ccccc4c3C2)C(=O)NCC2(CCCCC2)c2ccccn2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
