Reaction Details |
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Target | Hormone-sensitive lipase |
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Ligand | BDBM50147282 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_88045 (CHEMBL695907) |
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IC50 | 6±n/a nM |
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Citation | Lowe, DB; Magnuson, S; Qi, N; Campbell, AM; Cook, J; Hong, Z; Wang, M; Rodriguez, M; Achebe, F; Kluender, H; Wong, WC; Bullock, WH; Salhanick, AI; Witman-Jones, T; Bowling, ME; Keiper, C; Clairmont, KB In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase. Bioorg Med Chem Lett14:3155-9 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hormone-sensitive lipase |
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Name: | Hormone-sensitive lipase |
Synonyms: | HSL | Hormone sensitive lipase | Hormone-sensitive lipase (HSL) | LIPE | LIPS_HUMAN |
Type: | Protein |
Mol. Mass.: | 116599.07 |
Organism: | Homo sapiens (Human) |
Description: | Q05469 |
Residue: | 1076 |
Sequence: | MEPGSKSVSRSDWQPEPHQRPITPLEPGPEKTPIAQPESKTLQGSNTQQKPASNQRPLTQ
QETPAQHDAESQKEPRAQQKSASQEEFLAPQKPAPQQSPYIQRVLLTQQEAASQQGPGLG
KESITQQEPALRQRHVAQPGPGPGEPPPAQQEAESTPAAQAKPGAKREPSAPTESTSQET
PEQSDKQTTPVQGAKSKQGSLTELGFLTKLQELSIQRSALEWKALSEWVTDSESESDVGS
SSDTDSPATMGGMVAQGVKLGFKGKSGYKVMSGYSGTSPHEKTSARNHRHYQDTASRLIH
NMDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRLSGVFAGVREQALGLEPALGRLLGVAH
LFDLDPETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALT
QLRALVYYAQRLLVTNRPGVLFFEGDEGLTADFLREYVTLHKGCFYGRCLGFQFTPAIRP
FLQTISIGLVSFGEHYKRNETGLSVAASSLFTSGRFAIDPELRGAEFERITQNLDVHFWK
AFWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEMPLTADPTLTVTISPPLAHTGPGP
VLVRLISYDLREGQDSEELSSLIKSNGQRSLELWPRPQQAPRSRSLIVHFHGGGFVAQTS
RSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFAYCWAIKHCALLGSTGERIC
LAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQPAASPSRLLSLMDPLLPLSVL
SKCVSAYAGAKTEDHSNSDQKALGMMGLVRRDTALLLRDFRLGASSWLNSFLELSGRKSQ
KMSEPIAEPMRRSVSEAALAQPQGPLGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAET
LSPSTPSDVNFLLPPEDAGEEAEAKNELSPMDRGLGVRAAFPEGFHPRRSSQGATQMPLY
SSPIVKNPFMSPLLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVE
DLPHGFLTLAALCRETRQAAELCVERIRLVLTPPAGAGPSGETGAAGVDGGCGGRH
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BDBM50147282 |
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n/a |
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Name | BDBM50147282 |
Synonyms: | 3-Methyl-4-phenylsulfanyl-2-(piperidine-1-carbonyl)-2H-isoxazol-5-one | 3-methyl-4-(phenylthio)-2-(piperidine-1-carbonyl)isoxazol-5(2H)-one | CHEMBL106200 |
Type | Small organic molecule |
Emp. Form. | C16H18N2O3S |
Mol. Mass. | 318.391 |
SMILES | Cc1c(Sc2ccccc2)c(=O)on1C(=O)N1CCCCC1 |
Structure |
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