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TargetHeparanase
LigandBDBM50147522
Substrate/Competitorn/a
Meas. Tech.ChEBML_83907
IC50 400±n/a nM
Citation Courtney, SMHay, PABuck, RTColville, CSPorter, DWScopes, DIPollard, FCPage, MJBennett, JMHircock, MLMcKenzie, EAStubberfield, CRTurner, PR 2,3-Dihydro-1,3-dioxo-1H-isoindole-5-carboxylic acid derivatives: a novel class of small molecule heparanase inhibitors. Bioorg Med Chem Lett14:3269-73 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Heparanase
Name:Heparanase
Synonyms:Endo-glucoronidase | HEP | HPA | HPA1 | HPR1 | HPSE | HPSE1 | HPSE_HUMAN | HSE1 | Heparanase 50 kDa subunit | Heparanase 8 kDa subunit | Heparanase-1
Type:PROTEIN
Mol. Mass.:61167.67
Organism:Homo sapiens (Human)
Description:ChEMBL_327900
Residue:543
Sequence:
MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVT
IDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQS
QVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCS
GLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGS
QLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYL
NGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFA
AGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLM
ASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLL
RPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVA
ACI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50147522
n/a
NameBDBM50147522
Synonyms:2-(4-(butylamino)-3-(5-phenylbenzo[d]oxazol-2-yl)phenyl)-1,3-dioxoisoindoline-5-carboxylic acid | 2-[4-Butylamino-3-(5-phenyl-benzooxazol-2-yl)-phenyl]-1,3-dioxo-indan-5-carboxylic acid | CHEMBL321840
TypeSmall organic molecule
Emp. Form.C32H25N3O5
Mol. Mass.531.558
SMILESCCCCNc1ccc(cc1-c1nc2cc(ccc2o1)-c1ccccc1)N1C(=O)c2ccc(cc2C1=O)C(O)=O
Structure
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