Reaction Details |
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Target | Heparanase |
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Ligand | BDBM50147539 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_83907 |
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IC50 | 450±n/a nM |
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Citation | Courtney, SM; Hay, PA; Buck, RT; Colville, CS; Porter, DW; Scopes, DI; Pollard, FC; Page, MJ; Bennett, JM; Hircock, ML; McKenzie, EA; Stubberfield, CR; Turner, PR 2,3-Dihydro-1,3-dioxo-1H-isoindole-5-carboxylic acid derivatives: a novel class of small molecule heparanase inhibitors. Bioorg Med Chem Lett14:3269-73 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Heparanase |
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Name: | Heparanase |
Synonyms: | Endo-glucoronidase | HEP | HPA | HPA1 | HPR1 | HPSE | HPSE1 | HPSE_HUMAN | HSE1 | Heparanase 50 kDa subunit | Heparanase 8 kDa subunit | Heparanase-1 |
Type: | PROTEIN |
Mol. Mass.: | 61167.67 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_327900 |
Residue: | 543 |
Sequence: | MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVT
IDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQS
QVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCS
GLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGS
QLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYL
NGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFA
AGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLM
ASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLL
RPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVA
ACI
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BDBM50147539 |
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n/a |
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Name | BDBM50147539 |
Synonyms: | 2-(2-methoxy-5-(5-(4-methoxyphenyl)benzo[d]oxazol-2-yl)phenyl)-1,3-dioxoisoindoline-5-carboxylic acid | 2-{2-Methoxy-5-[5-(4-methoxy-phenyl)-benzooxazol-2-yl]-phenyl}-1,3-dioxo-indan-5-carboxylic acid | CHEMBL109779 |
Type | Small organic molecule |
Emp. Form. | C30H20N2O7 |
Mol. Mass. | 520.489 |
SMILES | COc1ccc(cc1)-c1ccc2oc(nc2c1)-c1ccc(OC)c(c1)N1C(=O)c2ccc(cc2C1=O)C(O)=O |
Structure |
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