Ki Summary

Reaction Details

Report a problem with these data

Target

Sphingosine 1-Phosphate Receptor 2

Ligand

BDBM50158348

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_201454

IC50

0.230000±n/a nM

Citation

Hale JJ; Neway W; Mills SG; Hajdu R; Ann Keohane C; Rosenbach M; Milligan J; Shei GJ; Chrebet G; Bergstrom J; Card D; Koo GC; Koprak SL; Jackson JJ; Rosen H; Mandala S Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720. Bioorg Med Chem Lett 14:3351-5 (2004) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Sphingosine 1-Phosphate Receptor 2

Name:

Sphingosine 1-phosphate receptor Edg-5/Sphingosine 1-phosphate receptor Edg-3

Synonyms:

S1P2 | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-5 | Sphingosine-1-phosphate receptor 2 | ndothelial differentiation G-protein coupled receptor 5

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

38883.16

Organism:

Homo sapiens (Human)

Description:

Membranes isolated from S1P2-transfected CHO cells were used in ligand binding assay.

Residue:

353

Sequence:

MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVAR
NSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASV
FSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACS
TVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLG
VFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVL
RPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV

BDBM50158348

n/a

Name

BDBM50158348

Synonyms:

(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate | (2S,3R,4E)-2-amino-4-octadecene-1,3-diol 1-(dihydrogen phosphate) | CHEMBL225155 | sphingosine 1-phosphate | sphingosine-1-phosphate

Type

Small organic molecule

Emp. Form.

C18H38NO5P

Mol. Mass.

379.4718

SMILES

CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O |r|

Structure