Reaction Details |
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Target | Sphingosine 1-phosphate receptor 4 |
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Ligand | BDBM50147713 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_201335 (CHEMBL806184) |
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IC50 | 23±n/a nM |
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Citation | Hale, JJ; Neway, W; Mills, SG; Hajdu, R; Ann Keohane, C; Rosenbach, M; Milligan, J; Shei, GJ; Chrebet, G; Bergstrom, J; Card, D; Koo, GC; Koprak, SL; Jackson, JJ; Rosen, H; Mandala, S Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720. Bioorg Med Chem Lett14:3351-5 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sphingosine 1-phosphate receptor 4 |
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Name: | Sphingosine 1-phosphate receptor 4 |
Synonyms: | EDG6 | Endothelial differentiation G-protein coupled receptor 6 | S1P receptor 4 | S1P receptor Edg-6 | S1P4 | S1PR4 | S1PR4_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-6 | Sphingosine-1-phosphate receptor 4 | sphingosine-1-phosphate 4 S1P4 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 41647.39 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 384 |
Sequence: | MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLV
VLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFL
REGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLP
LLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRP
AARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNS
AVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDS
FRGSRSLSFRMREPLSSISSVRSI
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BDBM50147713 |
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n/a |
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Name | BDBM50147713 |
Synonyms: | CHEMBL113344 | [3-Amino-1-hydroxy-5-(4-octyl-phenyl)-pentyl]-phosphonic acid |
Type | Small organic molecule |
Emp. Form. | C19H34NO4P |
Mol. Mass. | 371.4513 |
SMILES | CCCCCCCCc1ccc(CCC(N)CC(=O)P(O)(O)O)cc1 |
Structure |
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