Ki Summary

Reaction Details

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Target

Sphingosine 1-phosphate receptor Edg-5/Sphingosine 1-phosphate receptor Edg-3

Ligand

BDBM50148421

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_201323

IC50

>10000±n/a nM

Citation

Hale JJ; Doherty G; Toth L; Mills SG; Hajdu R; Keohane CA; Rosenbach M; Milligan J; Shei GJ; Chrebet G; Bergstrom J; Card D; Forrest M; Sun SY; West S; Xie H; Nomura N; Rosen H; Mandala S Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists. Bioorg Med Chem Lett 14:3501-5 (2004) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Sphingosine 1-phosphate receptor Edg-5/Sphingosine 1-phosphate receptor Edg-3

Name:

Sphingosine 1-phosphate receptor Edg-5/Sphingosine 1-phosphate receptor Edg-3

Synonyms:

S1P2 | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-5 | Sphingosine-1-phosphate receptor 2 | ndothelial differentiation G-protein coupled receptor 5

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

38883.16

Organism:

Homo sapiens (Human)

Description:

Membranes isolated from S1P2-transfected CHO cells were used in ligand binding assay.

Residue:

353

Sequence:

MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVAR
NSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASV
FSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACS
TVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLG
VFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVL
RPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV

BDBM50148421

n/a

Name

BDBM50148421

Synonyms:

CHEMBL119413 | [3-(3-Chloro-4-octyloxy-benzylamino)-propyl]-phosphonic acid

Type

Small organic molecule

Emp. Form.

C18H31ClNO4P

Mol. Mass.

391.87

SMILES

CCCCCCCCOc1ccc(CNCCCP(O)(O)=O)cc1Cl

Structure