| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM50148696 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_124496 |
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| IC50 | 6±n/a nM |
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| Citation |  Revesz, L; Blum, E; Di Padova, FE; Buhl, T; Feifel, R; Gram, H; Hiestand, P; Manning, U; Rucklin, G Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis. Bioorg Med Chem Lett14:3595-9 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | Crk1 | Csbp1 | Csbp2 | MAP Kinase p38 alpha | MAP kinase p38 | MK14_MOUSE | Mapk14 | Mitogen-activated protein kinase 14 | Mitogen-activated protein kinase p38 alpha |
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| Type: | Enzyme |
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| Mol. Mass.: | 41281.22 |
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| Organism: | Mus musculus (mouse) |
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| Description: | The full-length open reading frame of murine p38 alpha was cloned and expressed in E. coli.. Soluble murine p38R was extracted from cell pellets and purified using ion-exchange chromatography. |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM50148696 |
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| n/a |
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| Name | BDBM50148696 |
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| Synonyms: | CHEMBL119952 | {4-[(S)-2-(4-Fluoro-phenyl)-5-(4-methyl-piperazin-1-yl)-imidazo[4,5-b]pyridin-1-yl]-pyrimidin-2-yl}-(1-phenyl-ethyl)-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C29H29FN8 |
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| Mol. Mass. | 508.5926 |
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| SMILES | C[C@H](Nc1nccc(n1)-n1c(nc2nc(ccc12)N1CCN(C)CC1)-c1ccc(F)cc1)c1ccccc1 |
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| Structure | 
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