| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor VII |
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| Ligand | BDBM50148947 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_48454 |
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| Ki | 13±n/a nM |
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| Citation |  Klingler, O; Matter, H; Schudok, M; Donghi, M; Czech, J; Lorenz, M; Nestler, HP; Szillat, H; Schreuder, H Structure-based design of amidinophenylurea-derivatives for factor VIIa inhibition. Bioorg Med Chem Lett14:3715-20 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor VII |
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| Name: | Coagulation factor VII |
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| Synonyms: | Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator |
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| Type: | Enzyme |
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| Mol. Mass.: | 51599.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 466 |
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| Sequence: | MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
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| BDBM50148947 |
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| n/a |
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| Name | BDBM50148947 |
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| Synonyms: | CHEMBL339880 | Piperidine-4-carboxylic acid [4-(1-{2-[3-(4-carbamimidoyl-phenyl)-ureido]-acetylamino}-ethyl)-phenyl]-amide |
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| Type | Small organic molecule |
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| Emp. Form. | C24H31N7O3 |
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| Mol. Mass. | 465.548 |
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| SMILES | CC(NC(=O)CNC(=O)Nc1ccc(cc1)C(N)=N)c1ccc(NC(=O)C2CCNCC2)cc1 |
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| Structure | 
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