Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMelanocortin receptor 4
LigandBDBM50148982
Substrate/Competitorn/a
Meas. Tech.ChEBML_106507
Ki 9300.0±n/a nM
Citation Marsilje THRoses JBCalderwood EFStroud SGForsyth NEBlackburn CYowe DLMiao WDrabic SVBohane MDScott Daniels JLi PWu LPatane MAClaiborne CF Synthesis and biological evaluation of imidazole-based small molecule antagonists of the melanocortin 4 receptor (MC4-R). Bioorg Med Chem Lett 14:3721-5 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocortin receptor 4
Name:Melanocortin receptor 4
Synonyms:MC4-R | MC4R | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:Enzyme
Mol. Mass.:36949.50
Organism:Homo sapiens (Human)
Description:P32245
Residue:332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50148982
n/a
NameBDBM50148982
Synonyms:4-Bromo-2-{2-[2-chloro-6-(1-methyl-1H-imidazol-2-yl)-phenyl]-ethyl}-phenol | CHEMBL123660
TypeSmall organic molecule
Emp. Form.C18H16BrClN2O
Mol. Mass.391.689
SMILESCn1ccnc1-c1cccc(Cl)c1CCc1cc(Br)ccc1O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: