| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
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| Ligand | BDBM50148979 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_106507 |
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| Ki | 2500±n/a nM |
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| Citation |  Marsilje, TH; Roses, JB; Calderwood, EF; Stroud, SG; Forsyth, NE; Blackburn, C; Yowe, DL; Miao, W; Drabic, SV; Bohane, MD; Scott Daniels, J; Li, P; Wu, L; Patane, MA; Claiborne, CF Synthesis and biological evaluation of imidazole-based small molecule antagonists of the melanocortin 4 receptor (MC4-R). Bioorg Med Chem Lett14:3721-5 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 4 |
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| Name: | Melanocortin receptor 4 |
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| Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36949.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32245 |
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| Residue: | 332 |
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| Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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| BDBM50148979 |
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| n/a |
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| Name | BDBM50148979 |
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| Synonyms: | 2-{2-[2-(5-Bromo-2-methoxy-phenyl)-ethyl]-3-chloro-phenyl}-1-sec-butyl-1H-imidazole | CHEMBL122382 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24BrClN2O |
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| Mol. Mass. | 447.796 |
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| SMILES | CCC(C)n1ccnc1-c1cccc(Cl)c1CCc1cc(Br)ccc1OC |
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| Structure | 
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