| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
|---|
| Ligand | BDBM50148974 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_106507 |
|---|
| Ki | 180±n/a nM |
|---|
| Citation |  Marsilje, TH; Roses, JB; Calderwood, EF; Stroud, SG; Forsyth, NE; Blackburn, C; Yowe, DL; Miao, W; Drabic, SV; Bohane, MD; Scott Daniels, J; Li, P; Wu, L; Patane, MA; Claiborne, CF Synthesis and biological evaluation of imidazole-based small molecule antagonists of the melanocortin 4 receptor (MC4-R). Bioorg Med Chem Lett14:3721-5 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Melanocortin receptor 4 |
|---|
| Name: | Melanocortin receptor 4 |
|---|
| Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 36949.50 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P32245 |
|---|
| Residue: | 332 |
|---|
| Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
|
|
|
|---|
| BDBM50148974 |
|---|
| n/a |
|---|
| Name | BDBM50148974 |
|---|
| Synonyms: | 3-{2-[2-(5-Bromo-2-methoxy-phenyl)-ethyl]-3-chloro-phenyl}-6,7-dihydro-5H-pyrrolo[1,2-c]imidazole | CHEMBL123263 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H20BrClN2O |
|---|
| Mol. Mass. | 431.753 |
|---|
| SMILES | COc1ccc(Br)cc1CCc1c(Cl)cccc1-c1ncc2CCCn12 |
|---|
| Structure | 
|
|---|
Search and Browse
