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TargetCoagulation factor X
LigandBDBM50149079
Substrate/Competitorn/a
Meas. Tech.ChEBML_48487
IC50 150±n/a nM
Citation Mederski WWDorsch DAnzali SGleitz JCezanne BTsaklakidis C Halothiophene benzimidazoles as P1 surrogates of inhibitors of blood coagulation factor Xa. Bioorg Med Chem Lett 14:3763-9 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Thrombin and coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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  Blast E-value cutoff:
BDBM50149079
n/a
NameBDBM50149079
Synonyms:2-[2-(5-Chloro-thiophen-2-yl)-1H-benzoimidazol-5-yloxy]-N-[4-(3-oxo-morpholin-4-yl)-phenyl]-acetamide | CHEMBL123151
TypeSmall organic molecule
Emp. Form.C23H19ClN4O4S
Mol. Mass.482.939
SMILESClc1ccc(s1)-c1nc2ccc(OCC(=O)Nc3ccc(cc3)N3CCOCC3=O)cc2[nH]1
Structure
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