| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50149098 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_48487 |
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| IC50 | 7±n/a nM |
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| Citation |  Mederski, WW; Dorsch, D; Anzali, S; Gleitz, J; Cezanne, B; Tsaklakidis, C Halothiophene benzimidazoles as P1 surrogates of inhibitors of blood coagulation factor Xa. Bioorg Med Chem Lett14:3763-9 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50149098 |
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| n/a |
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| Name | BDBM50149098 |
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| Synonyms: | CHEMBL125552 | N-[3-Chloro-4-(3-oxo-morpholin-4-yl)-phenyl]-3-[2-(5-chloro-thiophen-2-yl)-1H-benzoimidazol-5-yl]-propionamide |
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| Type | Small organic molecule |
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| Emp. Form. | C24H20Cl2N4O3S |
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| Mol. Mass. | 515.412 |
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| SMILES | Clc1ccc(s1)-c1nc2ccc(CCC(=O)Nc3ccc(N4CCOCC4=O)c(Cl)c3)cc2[nH]1 |
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| Structure | 
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