| Reaction Details |
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 | Report a problem with these data |
| Target | Plasminogen activator inhibitor 1 |
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| Ligand | BDBM50149275 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_155742 (CHEMBL760892) |
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| Kd | 480±n/a nM |
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| Citation |  Elokdah, H; Abou-Gharbia, M; Hennan, JK; McFarlane, G; Mugford, CP; Krishnamurthy, G; Crandall, DL Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization. J Med Chem47:3491-4 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasminogen activator inhibitor 1 |
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| Name: | Plasminogen activator inhibitor 1 |
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| Synonyms: | Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1_RAT | Pai1 | Planh1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor-1 | Serpine1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45009.76 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_155741 |
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| Residue: | 402 |
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| Sequence: | MQMSSALTCLTLGLVLVFGKGFASPLPESHTAQQATNFGVKVFQHVVQASKDRNVVFSPY
GVSSVLAMLQLTTAGKTRQQIQDAMGFNISERGTAPALRKLSKELMGSWNKNEISTADAI
FVQRDLELVQGFMPHFFKLFRTTVKQVDFSEVERARFIINDWVERHTKGMISDLLAKGAV
NELTRLVLVNALYFNGQWKTPFLEASTHQRLFHKSDGSTISVPMMAQNNKFNYTEFTTPD
GHEYDILELPYHGETLSMFIAAPFEKDVPLSAITNILDAELIRQWKSNMTRLPRLLILPK
FSLETEVDLRGPLEKLGMTDIFSSTQADFTSLSDQEQLSVAQALQKVKIEVNESGTVASS
STAILVSARMAPTEMVLDRSFLFVVRHNPTETILFMGQLMEP
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| BDBM50149275 |
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| n/a |
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| Name | BDBM50149275 |
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| Synonyms: | 2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indol-3-yl)-2-oxoacetic acid | CHEMBL325441 | [1-Benzyl-5-(4-trifluoromethoxy-phenyl)-1H-indol-3-yl]-oxo-acetic acid | [{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C24H16F3NO4 |
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| Mol. Mass. | 439.3833 |
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| SMILES | OC(=O)C(=O)c1cn(Cc2ccccc2)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1 |
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| Structure | 
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