| Reaction Details |
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 | Report a problem with these data |
| Target | Methionine--tRNA ligase |
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| Ligand | BDBM50149632 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305245 (CHEMBL833503) |
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| IC50 | 17±n/a nM |
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| Citation |  Jarvest, RL; Armstrong, SA; Berge, JM; Brown, P; Elder, JS; Brown, MJ; Copley, RC; Forrest, AK; Hamprecht, DW; O'Hanlon, PJ; Mitchell, DJ; Rittenhouse, S; Witty, DR Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues. Bioorg Med Chem Lett14:3937-41 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Methionine--tRNA ligase |
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| Name: | Methionine--tRNA ligase |
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| Synonyms: | Methionyl-tRNA synthetase | SYM_STAAW | metG | metS |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74852.92 |
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| Organism: | Staphylococcus aureus (strain MW2) |
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| Description: | ChEMBL_305245 |
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| Residue: | 657 |
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| Sequence: | MAKETFYITTPIYYPSGNLHIGHAYSTVAGDVIARYKRMQGYDVRYLTGTDEHGQKIQEK
AQKAGKTEIEYLDEMIAGIKQLWAKLEISNDDFIRTTEERHKHVVEQVFERLLKQGDIYL
GEYEGWYSVPDETYYTESQLVDPQYENGKIIGGKSPDSGHEVELVKEESYFFNISKYTDR
LLEFYDQNPDFIQPPSRKNEMINNFIKPGLADLAVSRTSFNWGVHVPSNPKHVVYVWIDA
LVNYISALGYLSDDESLFNKYWPADIHLMAKEIVRFHSIIWPILLMALDLPLPKKVFAHG
WILMKDGKMSKSKGNVVDPNILIDRYGLDATRYYLMRELPFGSDGVFTPEAFVERTNFDL
ANDLGNLVNRTISMVNKYFDGELPAYQGPLHELDEEMEAMALETVKSYTESMESLQFSVA
LSTVWKFISRTNKYIDETTPWVLAKDDSQKDMLGNVMAHLVENIRYAAVLLRPFLTHAPK
EIFEQLNINNPQFMEFSSLEQYGVLTESIMVTGQPKPIFPRLDSEAEIAYIKESMQPPAT
EEEKEEIPSKPQIDIKDFDKVEIKAATIINAEHVKKSDKLLKIQVDLDSEQRQIVSGIAK
FYTPDDIIGKKVAVVTNLKPAKLMGQKSEGMILSAEKDGVLTLVSLPSAIPNGAVIK
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| BDBM50149632 |
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| n/a |
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| Name | BDBM50149632 |
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| Synonyms: | CHEMBL185486 | N-(1H-Benzoimidazol-2-yl)-N''-(3-bromo-2-ethoxy-5-methoxy-benzyl)-propane-1,3-diamine |
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| Type | Small organic molecule |
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| Emp. Form. | C20H25BrN4O2 |
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| Mol. Mass. | 433.342 |
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| SMILES | CCOc1c(Br)cc(OC)cc1CNCCCNc1nc2ccccc2[nH]1 |
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| Structure | 
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