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TargetMethionine--tRNA ligase
LigandBDBM50149643
Substrate/Competitorn/a
Meas. Tech.ChEMBL_305245 (CHEMBL833503)
IC50 6.2±n/a nM
Citation Jarvest, RLArmstrong, SABerge, JMBrown, PElder, JSBrown, MJCopley, RCForrest, AKHamprecht, DWO'Hanlon, PJMitchell, DJRittenhouse, SWitty, DR Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues. Bioorg Med Chem Lett14:3937-41 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Methionine--tRNA ligase
Name:Methionine--tRNA ligase
Synonyms:Methionyl-tRNA synthetase | SYM_STAAW | metG | metS
Type:PROTEIN
Mol. Mass.:74852.92
Organism:Staphylococcus aureus (strain MW2)
Description:ChEMBL_305245
Residue:657
Sequence:
MAKETFYITTPIYYPSGNLHIGHAYSTVAGDVIARYKRMQGYDVRYLTGTDEHGQKIQEK
AQKAGKTEIEYLDEMIAGIKQLWAKLEISNDDFIRTTEERHKHVVEQVFERLLKQGDIYL
GEYEGWYSVPDETYYTESQLVDPQYENGKIIGGKSPDSGHEVELVKEESYFFNISKYTDR
LLEFYDQNPDFIQPPSRKNEMINNFIKPGLADLAVSRTSFNWGVHVPSNPKHVVYVWIDA
LVNYISALGYLSDDESLFNKYWPADIHLMAKEIVRFHSIIWPILLMALDLPLPKKVFAHG
WILMKDGKMSKSKGNVVDPNILIDRYGLDATRYYLMRELPFGSDGVFTPEAFVERTNFDL
ANDLGNLVNRTISMVNKYFDGELPAYQGPLHELDEEMEAMALETVKSYTESMESLQFSVA
LSTVWKFISRTNKYIDETTPWVLAKDDSQKDMLGNVMAHLVENIRYAAVLLRPFLTHAPK
EIFEQLNINNPQFMEFSSLEQYGVLTESIMVTGQPKPIFPRLDSEAEIAYIKESMQPPAT
EEEKEEIPSKPQIDIKDFDKVEIKAATIINAEHVKKSDKLLKIQVDLDSEQRQIVSGIAK
FYTPDDIIGKKVAVVTNLKPAKLMGQKSEGMILSAEKDGVLTLVSLPSAIPNGAVIK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50149643
n/a
NameBDBM50149643
Synonyms:6-[3-(3,5-Dibromo-benzylamino)-propylamino]-7H-thieno[2,3-b]pyridin-4-one | CHEMBL368875
TypeSmall organic molecule
Emp. Form.C17H17Br2N3OS
Mol. Mass.471.209
SMILESOc1cc(NCCCNCc2cc(Br)cc(Br)c2)nc2sccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: