Reaction Details |
| Report a problem with these data |
Target | Methionine--tRNA ligase |
---|
Ligand | BDBM50409933 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_305245 (CHEMBL833503) |
---|
IC50 | 6.3±n/a nM |
---|
Citation | Jarvest, RL; Armstrong, SA; Berge, JM; Brown, P; Elder, JS; Brown, MJ; Copley, RC; Forrest, AK; Hamprecht, DW; O'Hanlon, PJ; Mitchell, DJ; Rittenhouse, S; Witty, DR Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues. Bioorg Med Chem Lett14:3937-41 (2004) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Methionine--tRNA ligase |
---|
Name: | Methionine--tRNA ligase |
Synonyms: | Methionyl-tRNA synthetase | SYM_STAAW | metG | metS |
Type: | PROTEIN |
Mol. Mass.: | 74852.92 |
Organism: | Staphylococcus aureus (strain MW2) |
Description: | ChEMBL_305245 |
Residue: | 657 |
Sequence: | MAKETFYITTPIYYPSGNLHIGHAYSTVAGDVIARYKRMQGYDVRYLTGTDEHGQKIQEK
AQKAGKTEIEYLDEMIAGIKQLWAKLEISNDDFIRTTEERHKHVVEQVFERLLKQGDIYL
GEYEGWYSVPDETYYTESQLVDPQYENGKIIGGKSPDSGHEVELVKEESYFFNISKYTDR
LLEFYDQNPDFIQPPSRKNEMINNFIKPGLADLAVSRTSFNWGVHVPSNPKHVVYVWIDA
LVNYISALGYLSDDESLFNKYWPADIHLMAKEIVRFHSIIWPILLMALDLPLPKKVFAHG
WILMKDGKMSKSKGNVVDPNILIDRYGLDATRYYLMRELPFGSDGVFTPEAFVERTNFDL
ANDLGNLVNRTISMVNKYFDGELPAYQGPLHELDEEMEAMALETVKSYTESMESLQFSVA
LSTVWKFISRTNKYIDETTPWVLAKDDSQKDMLGNVMAHLVENIRYAAVLLRPFLTHAPK
EIFEQLNINNPQFMEFSSLEQYGVLTESIMVTGQPKPIFPRLDSEAEIAYIKESMQPPAT
EEEKEEIPSKPQIDIKDFDKVEIKAATIINAEHVKKSDKLLKIQVDLDSEQRQIVSGIAK
FYTPDDIIGKKVAVVTNLKPAKLMGQKSEGMILSAEKDGVLTLVSLPSAIPNGAVIK
|
|
|
BDBM50409933 |
---|
n/a |
---|
Name | BDBM50409933 |
Synonyms: | CHEMBL2096779 |
Type | Small organic molecule |
Emp. Form. | C18H20Br2N6 |
Mol. Mass. | 480.2 |
SMILES | Brc1cc(Br)c2NCC[C@@H](NCCCNc3nc4ncccc4[nH]3)c2c1 |r| |
Structure |
|