Reaction Details |
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Target | 5-hydroxytryptamine receptor 1A |
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Ligand | BDBM50150084 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_904 (CHEMBL615753) |
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Ki | 5.8±n/a nM |
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Citation | Mewshaw, RE; Zhou, D; Zhou, P; Shi, X; Hornby, G; Spangler, T; Scerni, R; Smith, D; Schechter, LE; Andree, TH Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines. J Med Chem47:3823-42 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 1A |
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Name: | 5-hydroxytryptamine receptor 1A |
Synonyms: | 5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A |
Type: | n/a |
Mol. Mass.: | 46122.49 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 422 |
Sequence: | MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RQ
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BDBM50150084 |
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n/a |
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Name | BDBM50150084 |
Synonyms: | CHEMBL124700 | [2-(2,3-Dihydro-benzo[1,4]dioxin-5-yloxy)-ethyl]-[2-(5-fluoro-1H-indol-3-yl)-ethyl]-amine |
Type | Small organic molecule |
Emp. Form. | C20H21FN2O3 |
Mol. Mass. | 356.3907 |
SMILES | Fc1ccc2[nH]cc(CCNCCOc3cccc4OCCOc34)c2c1 |
Structure |
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