Reaction Details |
| Report a problem with these data |
Target | Polyunsaturated fatty acid lipoxygenase ALOX12 |
---|
Ligand | BDBM50150794 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_305339 (CHEMBL833559) |
---|
IC50 | 400±n/a nM |
---|
Citation | Segraves, EN; Shah, RR; Segraves, NL; Johnson, TA; Whitman, S; Sui, JK; Kenyon, VA; Cichewicz, RH; Crews, P; Holman, TR Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem47:4060-5 (2004) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Polyunsaturated fatty acid lipoxygenase ALOX12 |
---|
Name: | Polyunsaturated fatty acid lipoxygenase ALOX12 |
Synonyms: | 12-LOX | 12-Lipoxygenase (12-LOX) | 12LO | ALOX12 | Arachidonate 12-lipoxygenase | Arachidonate 12-lipoxygenase, 12S-type | LOG12 | LOX12_HUMAN | Platelet 12-lipoxygenase | Platelet-type lipoxygenase 12 |
Type: | Protein |
Mol. Mass.: | 75689.18 |
Organism: | Homo sapiens (Human) |
Description: | P18054 |
Residue: | 663 |
Sequence: | MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLL
QFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNA
LDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKA
GALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPML
LRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPL
VMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYH
LLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVST
GGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVH
LFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQH
AAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRR
QPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENS
VTI
|
|
|
BDBM50150794 |
---|
n/a |
---|
Name | BDBM50150794 |
Synonyms: | CHEMBL186752 | N-[2-(3-Bromo-4-hydroxy-phenyl)-ethyl]-3-[3,5-dibromo-4-(3-bromo-5-{2-[2-((E)-3-bromo-4-hydroxy-phenyl)-vinylcarbamoyl]-2-hydroxyimino-ethyl}-2-hydroxy-phenoxy)-phenyl]-2-[(E)-hydroxyimino]-propionamide |
Type | Small organic molecule |
Emp. Form. | C34H27Br5N4O8 |
Mol. Mass. | 1019.12 |
SMILES | Oc1ccc(CCNC(=O)C(Cc2cc(Br)c(Oc3cc(CC(N=O)C(=O)NC=Cc4ccc(O)c(Br)c4)cc(Br)c3O)c(Br)c2)N=O)cc1Br |w:29.29| |
Structure |
|