Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetGrowth hormone secretagogue receptor type 1
LigandBDBM50151169
Substrate/Competitorn/a
Meas. Tech.ChEMBL_303373 (CHEMBL839691)
Ki 1170±n/a nM
Citation Shoda, MHarada, TKogami, YTsujita, RAkashi, HKouji, HStahura, FLXue, LBajorath, J Identification of structurally diverse growth hormone secretagogue agonists by virtual screening and structure-activity relationship analysis of 2-formylaminoacetamide derivatives. J Med Chem47:4286-90 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Growth hormone secretagogue receptor type 1
Name:Growth hormone secretagogue receptor type 1
Synonyms:GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:Receptor
Mol. Mass.:41334.57
Organism:Homo sapiens (Human)
Description:Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50151169
n/a
NameBDBM50151169
Synonyms:5-Phenyl-1H-pyrrole-2-carboxylic acid [1-cyclohexylcarbamoyl-2-(5-methyl-furan-2-yl)-ethyl]-(3-diethylamino-propyl)-amide | CHEMBL186647
TypeSmall organic molecule
Emp. Form.C32H44N4O3
Mol. Mass.532.7168
SMILESCCN(CC)CCCN(C(Cc1ccc(C)o1)C(=O)NC1CCCCC1)C(=O)c1ccc([nH]1)-c1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: