Reaction Details |
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Target | Growth hormone secretagogue receptor type 1 |
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Ligand | BDBM50151169 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_303373 (CHEMBL839691) |
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Ki | 1170±n/a nM |
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Citation | Shoda, M; Harada, T; Kogami, Y; Tsujita, R; Akashi, H; Kouji, H; Stahura, FL; Xue, L; Bajorath, J Identification of structurally diverse growth hormone secretagogue agonists by virtual screening and structure-activity relationship analysis of 2-formylaminoacetamide derivatives. J Med Chem47:4286-90 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Growth hormone secretagogue receptor type 1 |
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Name: | Growth hormone secretagogue receptor type 1 |
Synonyms: | GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a) |
Type: | Receptor |
Mol. Mass.: | 41334.57 |
Organism: | Homo sapiens (Human) |
Description: | Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a. |
Residue: | 366 |
Sequence: | MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
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BDBM50151169 |
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n/a |
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Name | BDBM50151169 |
Synonyms: | 5-Phenyl-1H-pyrrole-2-carboxylic acid [1-cyclohexylcarbamoyl-2-(5-methyl-furan-2-yl)-ethyl]-(3-diethylamino-propyl)-amide | CHEMBL186647 |
Type | Small organic molecule |
Emp. Form. | C32H44N4O3 |
Mol. Mass. | 532.7168 |
SMILES | CCN(CC)CCCN(C(Cc1ccc(C)o1)C(=O)NC1CCCCC1)C(=O)c1ccc([nH]1)-c1ccccc1 |
Structure |
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