Reaction Details |
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Target | Metabotropic glutamate receptor 2 |
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Ligand | BDBM50151439 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_303460 (CHEMBL839720) |
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Ki | 1.48±n/a nM |
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Citation | Nakazato, A; Sakagami, K; Yasuhara, A; Ohta, H; Yoshikawa, R; Itoh, M; Nakamura, M; Chaki, S Synthesis, in vitro pharmacology, structure-activity relationships, and pharmacokinetics of 3-alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent and selective group II metabotropic glutamate receptor antagonists. J Med Chem47:4570-87 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Metabotropic glutamate receptor 2 |
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Name: | Metabotropic glutamate receptor 2 |
Synonyms: | GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2 |
Type: | Enzyme |
Mol. Mass.: | 95584.88 |
Organism: | Homo sapiens (Human) |
Description: | Q14416 |
Residue: | 872 |
Sequence: | MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL
ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA
RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
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BDBM50151439 |
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n/a |
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Name | BDBM50151439 |
Synonyms: | (1R,2R,3R,5R,6R)-2-Amino-3-[(R)-1-(3,4-dichloro-phenyl)-butoxy]-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid | CHEMBL365680 |
Type | Small organic molecule |
Emp. Form. | C18H20Cl2FNO5 |
Mol. Mass. | 420.26 |
SMILES | CCC[C@@H](O[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(N)C(O)=O)c1ccc(Cl)c(Cl)c1 |
Structure |
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