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TargetMelanocortin receptor 5
LigandBDBM50151511
Substrate/Competitorn/a
Meas. Tech.ChEMBL_302998 (CHEMBL830237)
Ki 5000±n/a nM
Citation Mutulis, F; Yahorava, S; Mutule, I; Yahorau, A; Liepinsh, E; Kopantshuk, S; Veiksina, S; Tars, K; Belyakov, S; Mishnev, A; Rinken, A; Wikberg, JE New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of"THIQ". J Med Chem47:4613-26 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocortin receptor 5
Name:Melanocortin receptor 5
Synonyms:MC-2 | MC5-R | MC5R | MC5R_HUMAN | Melanocortin MC5 | Melanocortin receptor (M4 and M5) | Melanocortin receptor 5 | Melanocortin receptor 5 (MC5R)
Type:Enzyme
Mol. Mass.:36612.92
Organism:Homo sapiens (Human)
Description:P33032
Residue:325
Sequence:
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGA
IVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDS
MICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILY
SESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTV
TMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQ
EMRKTFKEIICCRGFRIACSFPRRD
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  Blast E-value cutoff:
BDBM50151511
n/a
NameBDBM50151511
Synonyms:1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-amide | CHEMBL433750 | N-((R)-1-(4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpiperidin-1-yl)-3-(4-chlorophenyl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
TypeSmall organic molecule
Emp. Form.C33H41ClN6O2
Mol. Mass.589.171
SMILESClc1ccc(C[C@@H](NC(=O)C2Cc3ccccc3CN2)C(=O)N2CCC(Cn3cncn3)(CC2)C2CCCCC2)cc1
Structure
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