| Reaction Details |
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 | Report a problem with these data |
| Target | Sensory histidine kinase DcuS |
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| Ligand | BDBM50151872 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305474 (CHEMBL831083) |
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| IC50 | 303±n/a nM |
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| Citation |  Chan, WC; Coyle, BJ; Williams, P Virulence regulation and quorum sensing in staphylococcal infections: competitive AgrC antagonists as quorum sensing inhibitors. J Med Chem47:4633-41 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sensory histidine kinase DcuS |
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| Name: | Sensory histidine kinase DcuS |
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| Synonyms: | Receptor-histidine kinase AgrC |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49890.25 |
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| Organism: | Staphylococcus aureus |
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| Description: | ChEMBL_305973 |
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| Residue: | 430 |
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| Sequence: | MELLNSYNFVLFVLTQMILMFTIPAIISGIKYSKLDYFFIIVISTLSLFLFKMFDSASLI
ILTSFIIIMYFVKIKWYSILLIMTSQIILYCANYMYIVIYAYITKISDSIFVIFPSFFVV
YVTISILFSYIINRVLKKISTPYLILNKGFLIVISTILLLTFSLFFFYSQINSDEAKVIR
QYSFIFIGITIFLSILTFVISQFLLKEMKYKRNQEEIETYYEYTLKIEAINNEMRKFRHD
YVNILTTLSEYIREDDMPGLRDYFNKNIVPMKDNLQMNAIKLNGIENLKVREIKGLITAK
ILRAQEMNIPISIEIPDEVSSINLNMIDLSRSIGIILDNAIEASTEIDDPIIRVAFIESE
NSVTFIVMNKCADDIPRIHELFQESFSTKGEGRGLGLSTLKEIADNADNVLLDTIIENGF
FIQKVEIINN
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| BDBM50151872 |
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| n/a |
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| Name | BDBM50151872 |
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| Synonyms: | 2-{2-[4-(4-Benzoyl-phenoxy)-butyrylamino]-3-hydroxy-propionylamino}-N-[9-benzyl-6-sec-butyl-12-methyl-3-(2-methylsulfanyl-ethyl)-2,5,8,11,14-pentaoxo-1-thia-4,7,10,13-tetraaza-cyclohexadec-15-yl]-3-hydroxy-butyramide | CHEMBL262285 |
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| Type | Small organic molecule |
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| Emp. Form. | C50H65N7O12S2 |
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| Mol. Mass. | 1020.221 |
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| SMILES | CC[C@H](C)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)NC(=O)[C@@H](CSC(=O)[C@H](CCSC)NC1=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CCCOc1ccc(cc1)C(=O)c1ccccc1)[C@@H](C)O |
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| Structure | 
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