| Reaction Details |
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 | Report a problem with these data |
| Target | B2 bradykinin receptor |
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| Ligand | BDBM50151887 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302814 (CHEMBL839504) |
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| Ki | 1400±n/a nM |
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| Citation |  Ritchie, TJ; Dziadulewicz, EK; Culshaw, AJ; Müller, W; Burgess, GM; Bloomfield, GC; Drake, GS; Dunstan, AR; Beattie, D; Hughes, GA; Ganju, P; McIntyre, P; Bevan, SJ; Davis, C; Yaqoob, M Potent and orally bioavailable non-peptide antagonists at the human bradykinin B(1) receptor based on a 2-alkylamino-5-sulfamoylbenzamide core. J Med Chem47:4642-4 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B2 bradykinin receptor |
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| Name: | B2 bradykinin receptor |
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| Synonyms: | B2 BRADYKININ | B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKR2 | BKRB2_HUMAN | Bradykinin B2 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44467.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | B2 BRADYKININ BDKRB2 HUMAN::P30411 |
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| Residue: | 391 |
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| Sequence: | MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQ
PPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNN
FDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLV
IWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVI
TFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGI
LSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEP
IQMENSMGTLRTSISVERQIHKLQDWAGSRQ
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| BDBM50151887 |
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| n/a |
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| Name | BDBM50151887 |
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| Synonyms: | 4-(Benzhydryl-amino)-N,N-bis-(3-dimethylamino-propyl)-3-nitro-benzenesulfonamide | CHEMBL185068 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H39N5O4S |
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| Mol. Mass. | 553.716 |
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| SMILES | CN(C)CCCN(CCCN(C)C)S(=O)(=O)c1ccc(NC(c2ccccc2)c2ccccc2)c(c1)[N+]([O-])=O |
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| Structure | 
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