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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50152159 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_303525 (CHEMBL839639) | ||
| Ki | 7.3±n/a nM | ||
| Citation |  Chen, C; Wilcoxen, KM; Huang, CQ; Xie, YF; McCarthy, JR; Webb, TR; Zhu, YF; Saunders, J; Liu, XJ; Chen, TK; Bozigian, H; Grigoriadis, DE Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and structure--activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists. J Med Chem47:4787-98 (2004) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50152159 | |||
| n/a | |||
| Name | BDBM50152159 | ||
| Synonyms: | CHEMBL359784 | [3-(4,6-Dimethyl-pyridin-3-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-dipropyl-amine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H29N5 | ||
| Mol. Mass. | 351.4885 | ||
| SMILES | CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1cnc(C)cc1C |(7.42,1.73,;5.91,2.05,;4.89,.9,;3.37,1.21,;2.9,2.66,;3.91,3.81,;3.44,5.28,;2.35,.05,;2.84,-1.41,;1.81,-2.57,;2.29,-4.03,;.3,-2.24,;-.18,-.78,;-1.58,-.15,;-1.44,1.39,;-2.59,2.4,;.08,1.7,;.85,.37,;-2.91,-.94,;-2.91,-2.5,;-4.25,-3.26,;-5.58,-2.5,;-6.93,-3.26,;-5.58,-.94,;-4.25,-.17,;-4.27,1.39,)| | ||
| Structure | 
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