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TargetCorticotropin-releasing factor receptor 1
LigandBDBM50149669
Substrate/Competitorn/a
Meas. Tech.ChEMBL_303525 (CHEMBL839639)
Ki 9.1±n/a nM
Citation Chen, CWilcoxen, KMHuang, CQXie, YFMcCarthy, JRWebb, TRZhu, YFSaunders, JLiu, XJChen, TKBozigian, HGrigoriadis, DE Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and structure--activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists. J Med Chem47:4787-98 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Corticotropin-releasing factor receptor 1
Name:Corticotropin-releasing factor receptor 1
Synonyms:CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:Enzyme
Mol. Mass.:50744.31
Organism:Homo sapiens (Human)
Description:P34998
Residue:444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV
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  Blast E-value cutoff:
BDBM50149669
n/a
NameBDBM50149669
Synonyms:CHEMBL183148 | [2,5-Dimethyl-3-(3-methyl-5-nitro-pyridin-2-yl)-pyrazolo[1,5-a]pyrimidin-7-yl]-dipropyl-amine
TypeSmall organic molecule
Emp. Form.C20H26N6O2
Mol. Mass.382.4594
SMILESCCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ncc(cc1C)[N+]([O-])=O |(7.55,-.03,;6.02,.19,;5.44,1.62,;3.89,1.8,;3.31,3.23,;4.24,4.46,;3.66,5.89,;2.96,.58,;3.54,-.84,;2.61,-2.06,;3.19,-3.47,;1.08,-1.86,;.5,-.43,;-.95,.09,;-.91,1.62,;-2.12,2.55,;.57,2.06,;1.44,.77,;-2.36,-.59,;-2.36,-2.15,;-3.69,-2.91,;-5.03,-2.15,;-5.03,-.59,;-3.69,.19,;-3.69,1.72,;-6.36,-2.91,;-7.72,-2.15,;-6.36,-4.47,)|
Structure
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