Reaction Details |
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Target | DNA excision repair protein ERCC-5 |
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Ligand | BDBM50083934 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_304836 (CHEMBL827924) |
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IC50 | 12700±n/a nM |
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Citation | Tumey, LN; Huck, B; Gleason, E; Wang, J; Silver, D; Brunden, K; Boozer, S; Rundlett, S; Sherf, B; Murphy, S; Bailey, A; Dent, T; Leventhal, C; Harrington, J; Bennani, YL The identification and optimization of 2,4-diketobutyric acids as flap endonuclease 1 inhibitors. Bioorg Med Chem Lett14:4915-8 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA excision repair protein ERCC-5 |
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Name: | DNA excision repair protein ERCC-5 |
Synonyms: | ERCC5 | ERCC5_HUMAN | ERCM2 | XPG | XPGC |
Type: | PROTEIN |
Mol. Mass.: | 133069.11 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_305129 |
Residue: | 1186 |
Sequence: | MGVQGLWKLLECSGRQVSPEALEGKILAVDISIWLNQALKGVRDRHGNSIENPHLLTLFH
RLCKLLFFRIRPIFVFDGDAPLLKKQTLVKRRQRKDLASSDSRKTTEKLLKTFLKRQAIK
TAFRSKRDEALPSLTQVRRENDLYVLPPLQEEEKHSSEEEDEKEWQERMNQKQALQEEFF
HNPQAIDIESEDFSSLPPEVKHEILTDMKEFTKRRRTLFEAMPEESDDFSQYQLKGLLKK
NYLNQHIEHVQKEMNQQHSGHIRRQYEDEGGFLKEVESRRVVSEDTSHYILIKGIQAKTV
AEVDSESLPSSSKMHGMSFDVKSSPCEKLKTEKEPDATPPSPRTLLAMQAALLGSSSEEE
LESENRRQARGRNAPAAVDEGSISPRTLSAIKRALDDDEDVKVCAGDDVQTGGPGAEEMR
INSSTENSDEGLKVRDGKGIPFTATLASSSVNSAEEHVASTNEGREPTDSVPKEQMSLVH
VGTEAFPISDESMIKDRKDRLPLESAVVRHSDAPGLPNGRELTPASPTCTNSVSKNETHA
EVLEQQNELCPYESKFDSSLLSSDDETKCKPNSASEVIGPVSLQETSSIVSVPSEAVDNV
ENVVSFNAKEHENFLETIQEQQTTESAGQDLISIPKAVEPMEIDSEESESDGSFIEVQSV
ISDEELQAEFPETSKPPSEQGEEELVGTREGEAPAESESLLRDNSERDDVDGEPQEAEKD
AEDSLHEWQDINLEELETLESNLLAQQNSLKAQKQQQERIAATVTGQMFLESQELLRLFG
IPYIQAPMEAEAQCAILDLTDQTSGTITDDSDIWLFGARHVYRNFFNKNKFVEYYQYVDF
HNQLGLDRNKLINLAYLLGSDYTEGIPTVGCVTAMEILNEFPGHGLEPLLKFSEWWHEAQ
KNPKIRPNPHDTKVKKKLRTLQLTPGFPNPAVAEAYLKPVVDDSKGSFLWGKPDLDKIRE
FCQRYFGWNRTKTDESLFPVLKQLDAQQTQLRIDSFFRLAQQEKEDAKRIKSQRLNRAVT
CMLRKEKEAAASEIEAVSVAMEKEFELLDKAKGKTQKRGITNTLEESSSLKRKRLSDSKG
KNTCGGFLGETCLSESSDGSSSEDAESSSLMNVQRRTAAKEPKTSASDSQNSVKEAPVKN
GGATTSSSSDSDDDGGKEKMVLVTARSVFGKKRRKLRRARGRKRKT
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BDBM50083934 |
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n/a |
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Name | BDBM50083934 |
Synonyms: | 4-(4-Chloro-phenyl)-2-hydroxy-4-oxo-but-2-enoic acid | CHEMBL23545 | CHEMBL424806 |
Type | Small organic molecule |
Emp. Form. | C10H7ClO4 |
Mol. Mass. | 226.613 |
SMILES | OC(=O)C(=O)CC(=O)c1ccc(Cl)cc1 |
Structure |
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