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TargetDNA excision repair protein ERCC-5
LigandBDBM50152580
Substrate/Competitorn/a
Meas. Tech.ChEMBL_304836 (CHEMBL827924)
IC50 1400±n/a nM
Citation Tumey, LNHuck, BGleason, EWang, JSilver, DBrunden, KBoozer, SRundlett, SSherf, BMurphy, SBailey, ADent, TLeventhal, CHarrington, JBennani, YL The identification and optimization of 2,4-diketobutyric acids as flap endonuclease 1 inhibitors. Bioorg Med Chem Lett14:4915-8 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
DNA excision repair protein ERCC-5
Name:DNA excision repair protein ERCC-5
Synonyms:ERCC5 | ERCC5_HUMAN | ERCM2 | XPG | XPGC
Type:PROTEIN
Mol. Mass.:133069.11
Organism:Homo sapiens (Human)
Description:ChEMBL_305129
Residue:1186
Sequence:
MGVQGLWKLLECSGRQVSPEALEGKILAVDISIWLNQALKGVRDRHGNSIENPHLLTLFH
RLCKLLFFRIRPIFVFDGDAPLLKKQTLVKRRQRKDLASSDSRKTTEKLLKTFLKRQAIK
TAFRSKRDEALPSLTQVRRENDLYVLPPLQEEEKHSSEEEDEKEWQERMNQKQALQEEFF
HNPQAIDIESEDFSSLPPEVKHEILTDMKEFTKRRRTLFEAMPEESDDFSQYQLKGLLKK
NYLNQHIEHVQKEMNQQHSGHIRRQYEDEGGFLKEVESRRVVSEDTSHYILIKGIQAKTV
AEVDSESLPSSSKMHGMSFDVKSSPCEKLKTEKEPDATPPSPRTLLAMQAALLGSSSEEE
LESENRRQARGRNAPAAVDEGSISPRTLSAIKRALDDDEDVKVCAGDDVQTGGPGAEEMR
INSSTENSDEGLKVRDGKGIPFTATLASSSVNSAEEHVASTNEGREPTDSVPKEQMSLVH
VGTEAFPISDESMIKDRKDRLPLESAVVRHSDAPGLPNGRELTPASPTCTNSVSKNETHA
EVLEQQNELCPYESKFDSSLLSSDDETKCKPNSASEVIGPVSLQETSSIVSVPSEAVDNV
ENVVSFNAKEHENFLETIQEQQTTESAGQDLISIPKAVEPMEIDSEESESDGSFIEVQSV
ISDEELQAEFPETSKPPSEQGEEELVGTREGEAPAESESLLRDNSERDDVDGEPQEAEKD
AEDSLHEWQDINLEELETLESNLLAQQNSLKAQKQQQERIAATVTGQMFLESQELLRLFG
IPYIQAPMEAEAQCAILDLTDQTSGTITDDSDIWLFGARHVYRNFFNKNKFVEYYQYVDF
HNQLGLDRNKLINLAYLLGSDYTEGIPTVGCVTAMEILNEFPGHGLEPLLKFSEWWHEAQ
KNPKIRPNPHDTKVKKKLRTLQLTPGFPNPAVAEAYLKPVVDDSKGSFLWGKPDLDKIRE
FCQRYFGWNRTKTDESLFPVLKQLDAQQTQLRIDSFFRLAQQEKEDAKRIKSQRLNRAVT
CMLRKEKEAAASEIEAVSVAMEKEFELLDKAKGKTQKRGITNTLEESSSLKRKRLSDSKG
KNTCGGFLGETCLSESSDGSSSEDAESSSLMNVQRRTAAKEPKTSASDSQNSVKEAPVKN
GGATTSSSSDSDDDGGKEKMVLVTARSVFGKKRRKLRRARGRKRKT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50152580
n/a
NameBDBM50152580
Synonyms:4-[5-(4-Ethoxy-phenyl)-furan-2-yl]-2,4-dioxo-butyric acid | CHEMBL361460
TypeSmall organic molecule
Emp. Form.C16H14O6
Mol. Mass.302.2788
SMILESCCOc1ccc(cc1)-c1ccc(o1)C(=O)CC(=O)C(O)=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: