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TargetFlap endonuclease 1
LigandBDBM50152581
Substrate/Competitorn/a
Meas. Tech.ChEMBL_304758 (CHEMBL829355)
IC50 1360±n/a nM
Citation Tumey, LNHuck, BGleason, EWang, JSilver, DBrunden, KBoozer, SRundlett, SSherf, BMurphy, SBailey, ADent, TLeventhal, CHarrington, JBennani, YL The identification and optimization of 2,4-diketobutyric acids as flap endonuclease 1 inhibitors. Bioorg Med Chem Lett14:4915-8 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Flap endonuclease 1
Name:Flap endonuclease 1
Synonyms:DNase IV | FEN-1 | FEN1 | FEN1_HUMAN | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1
Type:PROTEIN
Mol. Mass.:42602.57
Organism:Homo sapiens (Human)
Description:ChEMBL_1517026
Residue:380
Sequence:
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGET
TSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAE
QEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDM
DCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRG
IGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSE
PNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEP
KGSTKKKAKTGAAGKFKRGK
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BDBM50152581
n/a
NameBDBM50152581
Synonyms:4-(4''-Methoxy-biphenyl-3-yl)-2,4-dioxo-butyric acid | CHEMBL185652
TypeSmall organic molecule
Emp. Form.C17H14O5
Mol. Mass.298.2901
SMILESCOc1ccc(cc1)-c1cccc(c1)C(=O)CC(=O)C(O)=O
Structure
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