| Reaction Details |
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 | Report a problem with these data |
| Target | Microsomal triglyceride transfer protein large subunit |
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| Ligand | BDBM50153193 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_312764 (CHEMBL833176) |
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| IC50 | 3±n/a nM |
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| Citation |  Sulsky, R; Robl, JA; Biller, SA; Harrity, TW; Wetterau, J; Connolly, F; Jolibois, K; Kunselman, L 5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP. Bioorg Med Chem Lett14:5067-70 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Microsomal triglyceride transfer protein large subunit |
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| Name: | Microsomal triglyceride transfer protein large subunit |
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| Synonyms: | MTP | MTP_HUMAN | MTTP | Microsomal triglyceride transfer protein | Microsomal triglyceride transfer protein large subunit |
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| Type: | PROTEIN |
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| Mol. Mass.: | 99365.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_971724 |
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| Residue: | 894 |
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| Sequence: | MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRIS
SNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQ
RPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQA
HQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGL
NFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKG
CPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLV
DAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIG
SSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNA
LLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVR
TAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEM
VAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLH
GSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSA
SGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKN
RVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQF
EKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF
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| BDBM50153193 |
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| n/a |
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| Name | BDBM50153193 |
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| Synonyms: | CHEMBL186836 | Trans-9-{4-[5-(2-Benzooxazol-2-yl-benzoylamino)-2-oxo-2lambda*5*-[1,3,2]dioxaphosphinan-2-yl]-butyl}-9H-fluorene-9-carboxylic acid (2,2,2-trifluoro-ethyl)-amide |
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| Type | Small organic molecule |
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| Emp. Form. | C37H33F3N3O6P |
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| Mol. Mass. | 703.6434 |
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| SMILES | FC(F)(F)CNC(=O)C1(CCCCP2(=O)OCC(CO2)NC(=O)c2ccccc2-c2nc3ccccc3o2)c2ccccc2-c2ccccc12 |
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| Structure | 
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