Reaction Details |
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Target | RNA-directed RNA polymerase |
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Ligand | BDBM50153254 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_306255 (CHEMBL828388) |
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IC50 | 4200±n/a nM |
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Citation | Stansfield, I; Avolio, S; Colarusso, S; Gennari, N; Narjes, F; Pacini, B; Ponzi, S; Harper, S Active site inhibitors of HCV NS5B polymerase. The development and pharmacophore of 2-thienyl-5,6-dihydroxypyrimidine-4-carboxylic acid. Bioorg Med Chem Lett14:5085-8 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RNA-directed RNA polymerase |
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Name: | RNA-directed RNA polymerase |
Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
Type: | Protein |
Mol. Mass.: | 25173.95 |
Organism: | Hepatitis C virus |
Description: | Q8JXU8 |
Residue: | 229 |
Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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BDBM50153254 |
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n/a |
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Name | BDBM50153254 |
Synonyms: | 5,6-dihydroxy-1-methyl-2-thiophen-2-yl-pyrimidine-4-carboxylic acid | 5-Hydroxy-1-methyl-6-oxo-2-thiophen-2-yl-1,6-dihydro-pyrimidine-4-carboxylic acid | 5-hydroxy-1-methyl-6-oxo-2-(thiophen-2-yl)-1,6-dihydropyrimidine-4-carboxylic acid | CHEMBL366051 |
Type | Small organic molecule |
Emp. Form. | C10H8N2O4S |
Mol. Mass. | 252.247 |
SMILES | Cn1c(nc(C(O)=O)c(O)c1=O)-c1cccs1 |
Structure |
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