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TargetRNA-directed RNA polymerase
LigandBDBM50153254
Substrate/Competitorn/a
Meas. Tech.ChEMBL_306255 (CHEMBL828388)
IC50 4200±n/a nM
Citation Stansfield, IAvolio, SColarusso, SGennari, NNarjes, FPacini, BPonzi, SHarper, S Active site inhibitors of HCV NS5B polymerase. The development and pharmacophore of 2-thienyl-5,6-dihydroxypyrimidine-4-carboxylic acid. Bioorg Med Chem Lett14:5085-8 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
RNA-directed RNA polymerase
Name:RNA-directed RNA polymerase
Synonyms:Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:Protein
Mol. Mass.:25173.95
Organism:Hepatitis C virus
Description:Q8JXU8
Residue:229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50153254
n/a
NameBDBM50153254
Synonyms:5,6-dihydroxy-1-methyl-2-thiophen-2-yl-pyrimidine-4-carboxylic acid | 5-Hydroxy-1-methyl-6-oxo-2-thiophen-2-yl-1,6-dihydro-pyrimidine-4-carboxylic acid | 5-hydroxy-1-methyl-6-oxo-2-(thiophen-2-yl)-1,6-dihydropyrimidine-4-carboxylic acid | CHEMBL366051
TypeSmall organic molecule
Emp. Form.C10H8N2O4S
Mol. Mass.252.247
SMILESCn1c(nc(C(O)=O)c(O)c1=O)-c1cccs1
Structure
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