Reaction Details |
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Target | Ribonucleoside-diphosphate reductase large subunit/subunit M2 |
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Ligand | BDBM50153688 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_306437 (CHEMBL829081) |
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IC50 | 13300±n/a nM |
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Citation | Tan, C; Gao, Y; Kaur, J; Cooperman, BS More potent linear peptide inhibitors of mammalian ribonucleotide reductase. Bioorg Med Chem Lett14:5301-4 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Ribonucleoside-diphosphate reductase large subunit/subunit M2 |
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Name: | Ribonucleoside-diphosphate reductase large subunit/subunit M2 |
Synonyms: | RRM1/RRM2 holoenzyme | Ribonucleoside-diphosphate reductase M1/M2 chain |
Type: | Enzyme |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Ribonucleoside-diphosphate reductase large subunit |
Synonyms: | RIR1_HUMAN | RR1 | RRM1 | Ribonucleoside-diphosphate reductase M1 chain | Ribonucleoside-diphosphate reductase subunit M1 | Ribonucleotide reductase large subunit |
Type: | PROTEIN |
Mol. Mass.: | 90074.67 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_90946 |
Residue: | 792 |
Sequence: | MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLA
AETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKST
LDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHK
EDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCAL
ISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIY
LEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLD
EVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNL
GTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKI
IDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGAL
EASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIA
PMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQII
ACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKL
TSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCS
LENRDECLMCGS
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Component 2 |
Name: | Ribonucleoside-diphosphate reductase subunit M2 |
Synonyms: | RIR2_HUMAN | RR2 | RRM2 | Ribonucleoside-diphosphate reductase M2 chain | Ribonucleotide reductase small chain | Ribonucleotide reductase small subunit |
Type: | PROTEIN |
Mol. Mass.: | 44868.59 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_195255 |
Residue: | 389 |
Sequence: | MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKT
KAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLK
PEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLI
DTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSF
ASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIE
QEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTN
FFEKRVGEYQRMGVMSSPTENSFTLDADF
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BDBM50153688 |
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n/a |
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Name | BDBM50153688 |
Synonyms: | (S)-3-[(S)-2-((S)-2-{(S)-2-[(2S,3R)-2-((S)-2-Acetylamino-3-phenyl-propionylamino)-3-hydroxy-butyrylamino]-4-methyl-pentanoylamino}-3-carboxy-propionylamino)-propionylamino]-N-((S)-1-carboxy-2-phenyl-ethyl)-succinamic acid | Ac-FTLDADF | AcFTLDADF | CHEMBL148859 |
Type | Small organic molecule |
Emp. Form. | C41H55N7O14 |
Mol. Mass. | 869.9139 |
SMILES | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(O)=O |r| |
Structure |
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