| Reaction Details |
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 | Report a problem with these data |
| Target | Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha |
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| Ligand | BDBM50153777 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305040 (CHEMBL831678) |
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| IC50 | 0.92±n/a nM |
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| Citation |  Li, Q; Wang, GT; Li, T; Gwaltney, SL; Woods, KW; Claiborne, A; Wang, X; Gu, W; Cohen, J; Stoll, VS; Hutchins, C; Frost, D; Rosenberg, SH; Sham, HL Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors. Bioorg Med Chem Lett14:5371-6 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha |
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| Name: | Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha |
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| Synonyms: | Protein Farnesyltransferase (PFT) | Protein farnesyltransferase |
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| Type: | Protein Complex |
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| Mol. Mass.: | n/a |
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| Description: | Purified bovine brain FTase. |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
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| Synonyms: | CAAX farnesyltransferase alpha subunit | FNTA | FNTA_BOVIN | FTase-alpha | GGTase-I-alpha | Geranylgeranyl Transferase (GGTase-I) Chain A | Protein Farnesyltransferase (PFT) Chain A | Protein farnesyltransferase | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit | Ras proteins prenyltransferase alpha | Type I protein geranyl-geranyltransferase alpha subunit |
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| Type: | Enzyme |
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| Mol. Mass.: | 43827.38 |
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| Organism: | Bos taurus (bovine) |
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| Description: | The enzyme was purified from a bovine brain homogenate by sequential ammonium sulfate fractionation and affinity chromatography. |
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| Residue: | 375 |
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| Sequence: | MAAADGVGEAAQGGDPGQPEPPPPPQPHPPPPPPQPPQEEAAAASPIDDGFLSLDSPTYV
LYRDRPEWADIDPVPQNDGPNPVVQIIYSEKFQDVYDYFRAVLQRDERSERAFKLTRDAI
ELNAANYTVWHFRRVLLKSLQKDLHEEMNYISAIIEEQPKNYQVWHHRRVLVEWLRDPSQ
ELEFIADILTQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVI
SNTTGYNDRAILEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLLDLQP
SHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQ
SKHSTESDPPTNVQQ
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| Component 2 |
| Name: | Protein farnesyltransferase subunit beta |
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| Synonyms: | CAAX farnesyltransferase subunit beta | FNTB | FNTB_BOVIN | FTase-beta | Protein farnesyltransferase | Protein farnesyltransferase beta subunit | Protein farnesyltransferase subunit beta | RAS proteins prenyltransferase beta | Ras proteins prenyltransferase subunit beta |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 48758.49 |
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| Organism: | Bos taurus (bovine) |
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| Description: | Protein farnesyltransferase subunit beta |
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| Residue: | 437 |
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| Sequence: | MASPSSFTYCCPPSSSPIWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFS
SYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQ
MVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDVINREKLLQY
LYSLKQPDGSFLMHDGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIG
GVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCY
SFWQAGLLPLLHRALHAQGDPALSMSRWMFHQQALQEYILMCCQCPTGGLLDKPGKSRDF
YHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATMHFLQKPV
PGFEEHEDEASAEPATD
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| BDBM50153777 |
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| n/a |
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| Name | BDBM50153777 |
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| Synonyms: | 4-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)methyl)-3-(naphthalen-2-yl)benzonitrile | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethyl]-3-naphthalen-2-yl-benzonitrile | CHEMBL184537 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H22N4O |
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| Mol. Mass. | 454.5219 |
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| SMILES | N#Cc1ccc(Cn2cncc2COCc2ccc(cc2-c2ccc3ccccc3c2)C#N)cc1 |
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| Structure | 
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