Reaction Details |
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Target | Mu-type opioid receptor |
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Ligand | BDBM50017698 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_302750 (CHEMBL852357) |
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Ki | 0.160000±n/a nM |
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Citation | Breslin, HJ; Miskowski, TA; Rafferty, BM; Coutinho, SV; Palmer, JM; Wallace, NH; Schneider, CR; Kimball, ES; Zhang, SP; Li, J; Colburn, RW; Stone, DJ; Martinez, RP; He, W Rationale, design, and synthesis of novel phenyl imidazoles as opioid receptor agonists for gastrointestinal disorders. J Med Chem47:5009-20 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mu-type opioid receptor |
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Name: | Mu-type opioid receptor |
Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 44503.11 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
Residue: | 398 |
Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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BDBM50017698 |
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n/a |
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Name | BDBM50017698 |
Synonyms: | 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N,N-dimethyl-2,2-diphenylbutanamide | 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-N,N-dimethyl-2,2-diphenyl-butyramide | 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-N,N-dimethyl-2,2-diphenyl-butyramide(loperamide) | CHEMBL841 | Imodium | LOPERAMIDE | LOPERAMIDE HYDROCHLORIDE | cid_71420 | med.21724, Compound 184 |
Type | Small organic molecule |
Emp. Form. | C29H33ClN2O2 |
Mol. Mass. | 477.038 |
SMILES | CN(C)C(=O)C(CCN1CCC(O)(CC1)c1ccc(Cl)cc1)(c1ccccc1)c1ccccc1 |
Structure |
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