| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase I |
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| Ligand | BDBM50154444 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305663 (CHEMBL828714) |
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| IC50 | >100000±n/a nM |
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| Citation |  Summa, V; Petrocchi, A; Matassa, VG; Taliani, M; Laufer, R; De Francesco, R; Altamura, S; Pace, P HCV NS5b RNA-dependent RNA polymerase inhibitors: from alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis. J Med Chem47:5336-9 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase I |
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| Name: | DNA polymerase I |
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| Synonyms: | DPO1_ECOLI | polA | resA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 103100.24 |
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| Organism: | Escherichia coli (strain K12) |
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| Description: | ChEMBL_305663 |
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| Residue: | 928 |
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| Sequence: | MVQIPQNPLILVDGSSYLYRAYHAFPPLTNSAGEPTGAMYGVLNMLRSLIMQYKPTHAAV
VFDAKGKTFRDELFEHYKSHRPPMPDDLRAQIEPLHAMVKAMGLPLLAVSGVEADDVIGT
LAREAEKAGRPVLISTGDKDMAQLVTPNITLINTMTNTILGPEEVVNKYGVPPELIIDFL
ALMGDSSDNIPGVPGVGEKTAQALLQGLGGLDTLYAEPEKIAGLSFRGAKTMAAKLEQNK
EVAYLSYQLATIKTDVELELTCEQLEVQQPAAEELLGLFKKYEFKRWTADVEAGKWLQAK
GAKPAAKPQETSVADEAPEVTATVISYDNYVTILDEETLKAWIAKLEKAPVFAFDTETDS
LDNISANLVGLSFAIEPGVAAYIPVAHDYLDAPDQISRERALELLKPLLEDEKALKVGQN
LKYDRGILANYGIELRGIAFDTMLESYILNSVAGRHDMDSLAERWLKHKTITFEEIAGKG
KNQLTFNQIALEEAGRYAAEDADVTLQLHLKMWPDLQKHKGPLNVFENIEMPLVPVLSRI
ERNGVKIDPKVLHNHSEELTLRLAELEKKAHEIAGEEFNLSSTKQLQTILFEKQGIKPLK
KTPGGAPSTSEEVLEELALDYPLPKVILEYRGLAKLKSTYTDKLPLMINPKTGRVHTSYH
QAVTATGRLSSTDPNLQNIPVRNEEGRRIRQAFIAPEDYVIVSADYSQIELRIMAHLSRD
KGLLTAFAEGKDIHRATAAEVFGLPLETVTSEQRRSAKAINFGLIYGMSAFGLARQLNIP
RKEAQKYMDLYFERYPGVLEYMERTRAQAKEQGYVETLDGRRLYLPDIKSSNGARRAAAE
RAAINAPMQGTAADIIKRAMIAVDAWLQAEQPRVRMIMQVHDELVFEVHKDDVDAVAKQI
HQLMENCTRLDVPLLVEVGSGENWDQAH
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| BDBM50154444 |
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| n/a |
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| Name | BDBM50154444 |
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| Synonyms: | 2-(3-Benzyloxy-phenyl)-5,6-dihydroxy-pyrimidine-4-carboxylic acid | CHEMBL188307 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14N2O5 |
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| Mol. Mass. | 338.3142 |
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| SMILES | OC(=O)c1nc([nH]c(=O)c1O)-c1cccc(OCc2ccccc2)c1 |
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| Structure | 
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