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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Vascular endothelial growth factor receptor 2 | ||
| Ligand | BDBM50155150 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_306585 (CHEMBL832932) | ||
| IC50 | 840.0±n/a nM | ||
| Citation |  Cusack, KP; Arnold, LD; Barberis, CE; Chen, H; Ericsson, AM; Gaza-Bulseco, GS; Gordon, TD; Grinnell, CM; Harsch, A; Pellegrini, M; Tarcsa, E A 13C NMR approach to categorizing potential limitations of alpha,beta-unsaturated carbonyl systems in drug-like molecules. Bioorg Med Chem Lett14:5503-7 (2004) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Vascular endothelial growth factor receptor 2 | |||
| Name: | Vascular endothelial growth factor receptor 2 | ||
| Synonyms: | CD_antigen=CD309 | FLK1 | Fetal liver kinase 1 (FLK-1) | Flk-1/KDR | KDR | Kinase Insert Domain Receptor | Protein-tyrosine kinase receptor Flk-1 | VEGFR kinase (KDR) | VEGFR-2 | VEGFR-2 (KDR) | VEGFR2 | VGFR2_HUMAN | Vascular Endothelial Growth Factor Receptor Kinase 2 | Vascular endothelial growth factor receptor (VEGFR-2) | Vascular endothelial growth factor receptor 2 (KDR) | Vascular endothelial growth factor receptor 2 (VEGFR-2) | Vascular endothelial growth factor receptor 2 (VEGFR2) | Vascular endothelial growth factor receptor 2 precursor (VEGFR-2) | Vascular endothelial growth factor receptor-2 (VEGFR-2) | ||
| Type: | Receptor Tyrosine Kinase | ||
| Mol. Mass.: | 151510.97 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P35968 | ||
| Residue: | 1356 | ||
| Sequence: |
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| BDBM50155150 | |||
| n/a | |||
| Name | BDBM50155150 | ||
| Synonyms: | 5-Cyclopropyl-4-[4-(2-diethylamino-ethyl)-3,5-dimethyl-1H-pyrrol-2-ylmethylene]-2,4-dihydro-pyrazol-3-one | CHEMBL187279 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H28N4O | ||
| Mol. Mass. | 328.4518 | ||
| SMILES | CCN(CC)CCc1c(C)[nH]c(C=c2c(=O)[nH][nH]c2=C2CC2)c1C |w:12.11,(6.74,1.52,;6.25,2.98,;4.76,3.31,;4.27,4.76,;2.76,5.08,;3.73,2.15,;2.22,2.47,;1.2,1.32,;1.68,-.12,;3.14,-.61,;.44,-1.03,;-.82,-.15,;-2.28,-.63,;-2.59,-2.12,;-1.56,-3.28,;-.02,-3.11,;-2.33,-4.61,;-3.84,-4.29,;-4.01,-2.76,;-5.34,-1.99,;-6.11,-.68,;-6.88,-2.01,;-.34,1.32,;-1.24,2.57,)| | ||
| Structure | 
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