Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCyclin-dependent kinase 5
LigandBDBM50155213
Substrate/Competitorn/a
Meas. Tech.ChEMBL_306160 (CHEMBL832348)
IC50 5±n/a nM
Citation Helal, CJSanner, MACooper, CBGant, TAdam, MLucas, JCKang, ZKupchinsky, SAhlijanian, MKTate, BMenniti, FSKelly, KPeterson, M Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer's disease. Bioorg Med Chem Lett14:5521-5 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 5
Name:Cyclin-dependent kinase 5
Synonyms:CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit
Type:Enzyme Subunit
Mol. Mass.:33308.61
Organism:Homo sapiens (Human)
Description:n/a
Residue:292
Sequence:
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH
KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR
NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS
TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP
MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50155213
n/a
NameBDBM50155213
Synonyms:1-(5-Cyclobutyl-thiazol-2-yl)-3-isoquinolin-8-yl-urea | CHEMBL186342
TypeSmall organic molecule
Emp. Form.C17H16N4OS
Mol. Mass.324.4
SMILESO=C(Nc1ncc(s1)C1CCC1)Nc1cccc2ccncc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: