Ki Summary

Reaction Details

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Target

Gonadotropin-releasing hormone receptor

Ligand

BDBM50155362

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_306727 (CHEMBL831490)

IC50

0.6±n/a nM

Citation

DeVita, RJ; Parikh, M; Jiang, J; Fair, JA; Young, JR; Walsh, TF; Goulet, MT; Lo, JL; Ren, N; Yudkovitz, JB; Cui, J; Yang, YT; Cheng, K; Rohrer, SP; Wyvratt, MJ Identification of neutral 4-O-alkyl quinolone nonpeptide GnRH receptor antagonists. Bioorg Med Chem Lett14:5599-603 (2004) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gonadotropin-releasing hormone receptor

Name:

Gonadotropin-releasing hormone receptor

Synonyms:

Type:

Enzyme

Mol. Mass.:

37749.45

Organism:

Homo sapiens (Human)

Description:

P30968

Residue:

328

Sequence:

MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL

BDBM50155362

n/a

Name

BDBM50155362

Synonyms:

4-[2-(1-Aza-bicyclo[2.2.2]oct-2-yl)-ethoxy]-7-chloro-2-oxo-3-(3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid [1,2,5]thiadiazol-3-ylamide | CHEMBL185986

Type

Small organic molecule

Emp. Form.

C30H32ClN5O3S

Mol. Mass.

578.125

SMILES

Cc1cc(cc(C)c1C)-c1c(OCCC2CC3CCN2CC3)c2cc(C(=O)Nc3cnsn3)c(Cl)cc2[nH]c1=O |(5.79,2.75,;5.81,1.21,;4.48,.44,;4.48,-1.1,;5.81,-1.87,;7.14,-1.1,;8.47,-1.87,;7.14,.44,;8.48,1.21,;3.13,-1.85,;1.8,-1.07,;1.8,.47,;.47,1.24,;.47,2.78,;-.86,3.55,;-2.19,2.77,;-3.52,3.55,;-2.94,4.71,;-1.45,4.29,;-.86,5.09,;-2.19,5.87,;-3.52,5.09,;.47,-1.85,;-.86,-1.07,;-2.19,-1.85,;-3.52,-1.1,;-3.52,.44,;-4.87,-1.87,;-6.2,-1.1,;-7.62,-1.7,;-8.63,-.56,;-7.88,.77,;-6.36,.44,;-2.19,-3.41,;-3.54,-4.18,;-.86,-4.18,;.47,-3.39,;1.8,-4.18,;3.13,-3.41,;4.46,-4.18,)|

Structure