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TargetProlyl endopeptidase
LigandBDBM50155836
Substrate/Competitorn/a
Meas. Tech.ChEMBL_302659 (CHEMBL839948)
Ki 0.15±n/a nM
Citation Jarho, EMVenäläinen, JIHuuskonen, JChristiaans, JAGarcia-Horsman, JAForsberg, MMJärvinen, TGynther, JMännistö, PTWallén, EA A cyclopent-2-enecarbonyl group mimics proline at the P2 position of prolyl oligopeptidase inhibitors. J Med Chem47:5605-7 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prolyl endopeptidase
Name:Prolyl endopeptidase
Synonyms:3.4.21.26 | PE | PPCE_PIG | PREP | Post-proline cleaving enzyme
Type:n/a
Mol. Mass.:80758.04
Organism:Sus scrofa
Description:n/a
Residue:710
Sequence:
MLSFQYPDVYRDETAIQDYHGHKVCDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIR
GLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILS
DDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTH
DGKGMFYNAYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAEL
SDDGRYVLLSIREGCDPVNRLWYCDLQQESNGITGILKWVKLIDNFEGEYDYVTNEGTVF
TFKTNRHSPNYRLINIDFTDPEESKWKVLVPEHEKDVLEWVACVRSNFLVLCYLHDVKNT
LQLHDLATGALLKIFPLEVGSVVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPR
VFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISI
TPNYSVSRLIFVRHMGGVLAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE
GYTSPKRLTINGGSNGGLLVATCANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYG
CSDSKQHFEWLIKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIV
GRSRKQNNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNIDWIP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50155836
n/a
NameBDBM50155836
Synonyms:(R)-5-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carbonyl]-cyclopent-1-enecarboxylic acid benzylamide | CHEMBL365843
TypeSmall organic molecule
Emp. Form.C20H24N2O4
Mol. Mass.356.4156
SMILESOCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCC=C1C(=O)NCc1ccccc1 |c:15|
Structure
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