Reaction Details |
| Report a problem with these data |
Target | Corticotropin-releasing factor receptor 1 |
---|
Ligand | BDBM50155964 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_306679 (CHEMBL830013) |
---|
IC50 | 0.5±n/a nM |
---|
Citation | Dzierba, CD; Takvorian, AG; Rafalski, M; Kasireddy-Polam, P; Wong, H; Molski, TF; Zhang, G; Li, YW; Lelas, S; Peng, Y; McElroy, JF; Zaczek, RC; Taub, RA; Combs, AP; Gilligan, PJ; Trainor, GL Synthesis, structure-activity relationships, and in vivo properties of 3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-ones as corticotropin-releasing factor-1 receptor antagonists. J Med Chem47:5783-90 (2004) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Corticotropin-releasing factor receptor 1 |
---|
Name: | Corticotropin-releasing factor receptor 1 |
Synonyms: | CRF-R | CRF1 | CRFR1_RAT | CRH-R 1 | Corticotropin releasing factor receptor | Corticotropin releasing factor receptor 1 | Corticotropin-releasing Factor Receptor 1 | Corticotropin-releasing hormone receptor 1 | Crhr | Crhr1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 47870.75 |
Organism: | Rattus norvegicus (rat) |
Description: | Receptor binding assays were performed using rat cortex homogenate. |
Residue: | 415 |
Sequence: | MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEV
HQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPF
PIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA
STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS
VFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
|
|
|
BDBM50155964 |
---|
n/a |
---|
Name | BDBM50155964 |
Synonyms: | 8-(Butyl-ethyl-amino)-4-(2-chloro-5-fluoro-4-methoxy-phenyl)-6-methyl-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one; TFA | CHEMBL188464 |
Type | Small organic molecule |
Emp. Form. | C21H26ClFN4O2 |
Mol. Mass. | 420.908 |
SMILES | CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1cc(F)c(OC)cc1Cl |
Structure |
|