| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisomal acyl-coenzyme A oxidase 1 |
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| Ligand | BDBM50156430 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_311972 (CHEMBL834389) |
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| IC50 | 120±n/a nM |
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| Citation |  Elzein, E; Ibrahim, P; Koltun, DO; Rehder, K; Shenk, KD; Marquart, TA; Jiang, B; Li, X; Natero, R; Li, Y; Nguyen, M; Kerwar, S; Chu, N; Soohoo, D; Hao, J; Maydanik, VY; Lustig, DA; Zeng, D; Leung, K; Zablocki, JA CVT-4325: a potent fatty acid oxidation inhibitor with favorable oral bioavailability. Bioorg Med Chem Lett14:6017-21 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisomal acyl-coenzyme A oxidase 1 |
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| Name: | Peroxisomal acyl-coenzyme A oxidase 1 |
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| Synonyms: | ACOX1_RAT | AOX | Acox | Acox1 | Palmitoyl-CoA oxidase | Peroxisomal acyl-CoA oxidase 1, A chain | Peroxisomal acyl-CoA oxidase 1, B chain | Peroxisomal acyl-CoA oxidase 1, C chain | Peroxisomal acyl-coenzyme A oxidase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74693.04 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_311972 |
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| Residue: | 661 |
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| Sequence: | MNPDLRKERASATFNPELITHILDGSPENTRRRREIENLILNDPDFQHEDYNFLTRSQRY
EVAVKKSATMVKKMREYGISDPEEIMWFKKLYLANFVEPVGLNYSMFIPTLLNQGTTAQQ
EKWMRPSQELQIIGTYAQTEMGHGTHLRGLETTATYDPKTQEFILNSPTVTSIKWWPGGL
GKTSNHAIVLAQLITQGECYGLHAFVVPIREIGTHKPLPGITVGDIGPKFGYEEMDNGYL
KMDNYRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGNAAQSLSKACTIA
IRYSAVRRQSEIKQSEPEPQILDFQTQQYKLFPLLATAYAFHFVGRYMKETYLRINESIG
QGDLSELPELHALTAGLKAFTTWTANAGIEECRMACGGHGYSHSSGIPNIYVTFTPACTF
EGENTVMMLQTARFLMKIYDQVRSGKLVGGMVSYLNDLPSQRIQPQQVAVWPTMVDINSL
EGLTEAYKLRAARLVEIAAKNLQTHVSHRKSKEVAWNLTSVDLVRASEAHCHYVVVKVFS
DKLPKIQDKAVQAVLRNLCLLYSLYGISQKGGDFLEGSIITGAQLSQVNARILELLTLIR
PNAVALVDAFDFKDMTLGSVLGRYDGNVYENLFEWAKKSPLNKTEVHESYHKHLKPLQSK
L
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| BDBM50156430 |
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| n/a |
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| Name | BDBM50156430 |
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| Synonyms: | (R)-1-{(S)-4-[5-(2,4-Dichloro-phenyl)-[1,2,4]oxadiazol-3-ylmethyl]-2-methyl-piperazin-1-yl}-3-(2-methyl-benzothiazol-5-yloxy)-propan-2-ol | CHEMBL185174 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27Cl2N5O3S |
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| Mol. Mass. | 548.485 |
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| SMILES | C[C@H]1CN(Cc2noc(n2)-c2ccc(Cl)cc2Cl)CCN1C[C@@H](O)COc1ccc2sc(C)nc2c1 |
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| Structure | 
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