Reaction Details |
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Target | Peroxisomal acyl-coenzyme A oxidase 1 |
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Ligand | BDBM50156441 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_311972 (CHEMBL834389) |
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IC50 | 1560±n/a nM |
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Citation | Elzein, E; Ibrahim, P; Koltun, DO; Rehder, K; Shenk, KD; Marquart, TA; Jiang, B; Li, X; Natero, R; Li, Y; Nguyen, M; Kerwar, S; Chu, N; Soohoo, D; Hao, J; Maydanik, VY; Lustig, DA; Zeng, D; Leung, K; Zablocki, JA CVT-4325: a potent fatty acid oxidation inhibitor with favorable oral bioavailability. Bioorg Med Chem Lett14:6017-21 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Peroxisomal acyl-coenzyme A oxidase 1 |
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Name: | Peroxisomal acyl-coenzyme A oxidase 1 |
Synonyms: | ACOX1_RAT | AOX | Acox | Acox1 | Palmitoyl-CoA oxidase | Peroxisomal acyl-CoA oxidase 1, A chain | Peroxisomal acyl-CoA oxidase 1, B chain | Peroxisomal acyl-CoA oxidase 1, C chain | Peroxisomal acyl-coenzyme A oxidase 1 |
Type: | PROTEIN |
Mol. Mass.: | 74693.04 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_311972 |
Residue: | 661 |
Sequence: | MNPDLRKERASATFNPELITHILDGSPENTRRRREIENLILNDPDFQHEDYNFLTRSQRY
EVAVKKSATMVKKMREYGISDPEEIMWFKKLYLANFVEPVGLNYSMFIPTLLNQGTTAQQ
EKWMRPSQELQIIGTYAQTEMGHGTHLRGLETTATYDPKTQEFILNSPTVTSIKWWPGGL
GKTSNHAIVLAQLITQGECYGLHAFVVPIREIGTHKPLPGITVGDIGPKFGYEEMDNGYL
KMDNYRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGNAAQSLSKACTIA
IRYSAVRRQSEIKQSEPEPQILDFQTQQYKLFPLLATAYAFHFVGRYMKETYLRINESIG
QGDLSELPELHALTAGLKAFTTWTANAGIEECRMACGGHGYSHSSGIPNIYVTFTPACTF
EGENTVMMLQTARFLMKIYDQVRSGKLVGGMVSYLNDLPSQRIQPQQVAVWPTMVDINSL
EGLTEAYKLRAARLVEIAAKNLQTHVSHRKSKEVAWNLTSVDLVRASEAHCHYVVVKVFS
DKLPKIQDKAVQAVLRNLCLLYSLYGISQKGGDFLEGSIITGAQLSQVNARILELLTLIR
PNAVALVDAFDFKDMTLGSVLGRYDGNVYENLFEWAKKSPLNKTEVHESYHKHLKPLQSK
L
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BDBM50156441 |
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n/a |
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Name | BDBM50156441 |
Synonyms: | (R)-1-{4-[3-(3,4-Dichloro-phenyl)-[1,2,4]oxadiazol-5-ylmethyl]-piperazin-1-yl}-3-(2-methyl-benzothiazol-5-yloxy)-propan-2-ol | CHEMBL185771 |
Type | Small organic molecule |
Emp. Form. | C24H25Cl2N5O3S |
Mol. Mass. | 534.458 |
SMILES | Cc1nc2cc(OC[C@H](O)CN3CCN(Cc4nc(no4)-c4ccc(Cl)c(Cl)c4)CC3)ccc2s1 |
Structure |
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