Reaction Details | |||
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Target | Androgen receptor | ||
Ligand | BDBM18162 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_303250 (CHEMBL826376) | ||
Ki | 1±n/a nM | ||
Citation | Balog, A; Salvati, ME; Shan, W; Mathur, A; Leith, LW; Wei, DD; Attar, RM; Geng, J; Rizzo, CA; Wang, C; Krystek, SR; Tokarski, JS; Hunt, JT; Gottardis, M; Weinmann, R The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgen receptor antagonists. Bioorg Med Chem Lett14:6107-11 (2004) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Androgen receptor | |||
Name: | Androgen receptor | ||
Synonyms: | ANDR_HUMAN | AR | Androgen Receptor | Androgen receptor (AR) | Androgen receptor/Baculoviral IAP repeat-containing protein 2 | DHTR | Dihydrotestosterone receptor | NR3C4 | Nuclear receptor subfamily 3 group C member 4 | ||
Type: | Receptor | ||
Mol. Mass.: | 99185.27 | ||
Organism: | Homo sapiens (Human) | ||
Description: | CHO cells were stably transfected with human AR gene. | ||
Residue: | 920 | ||
Sequence: |
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BDBM18162 | |||
n/a | |||
Name | BDBM18162 | ||
Synonyms: | (1R,6R,7S)-4-(4-nitronaphthalen-1-yl)-2,4-diazatricyclo[5.2.1.0^{2,6}]decane-3,5-dione | CHEMBL185880 | N-aryl-bicyclic hydantoin, 4a | ||
Type | Small organic molecule | ||
Emp. Form. | C18H15N3O4 | ||
Mol. Mass. | 337.3294 | ||
SMILES | Oc1c2[C@H]3CC[C@H](C3)n2c(=O)n1-c1ccc([N+]([O-])=O)c2ccccc12 |r,wU:6.6,3.7,(12.2,-7.28,;12.6,-8.77,;11.56,-9.96,;10.02,-9.96,;9.25,-11.29,;10.02,-12.62,;11.56,-12.62,;10.02,-11.73,;12.33,-11.29,;13.87,-10.92,;15.03,-11.93,;14,-9.4,;15.49,-9,;16.07,-7.57,;17.59,-7.36,;18.54,-8.57,;20.06,-8.36,;20.83,-9.69,;20.64,-6.93,;17.96,-10,;18.91,-11.21,;18.34,-12.64,;16.81,-12.86,;15.86,-11.64,;16.44,-10.22,)| | ||
Structure |