| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prostaglandin E2 receptor EP4 subtype |
|---|
| Ligand | BDBM50142481 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_429536 (CHEMBL918077) |
|---|
| Ki | 4.5±n/a nM |
|---|
| Citation |  Elworthy, TR; Brill, ER; Chiou, SS; Chu, F; Harris, JR; Hendricks, RT; Huang, J; Kim, W; Lach, LK; Mirzadegan, T; Yee, C; Walker, KA Lactams as EP4 prostanoid receptor agonists. 3. Discovery of N-ethylbenzoic acid 2-pyrrolidinones as subtype selective agents. J Med Chem47:6124-7 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prostaglandin E2 receptor EP4 subtype |
|---|
| Name: | Prostaglandin E2 receptor EP4 subtype |
|---|
| Synonyms: | PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 53134.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P35408 |
|---|
| Residue: | 488 |
|---|
| Sequence: | MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG
LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA
INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA
HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG
HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQP
SLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSG
QHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPG
MGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSET
LNLSEKCI
|
|
|
|---|
| BDBM50142481 |
|---|
| n/a |
|---|
| Name | BDBM50142481 |
|---|
| Synonyms: | 7-[(R)-2-((E)-(S)-3-Hydroxy-oct-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid | 8-aza-11-deoxyprostaglandin E1 | CHEMBL42027 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H33NO4 |
|---|
| Mol. Mass. | 339.4696 |
|---|
| SMILES | CCCCC[C@H](O)\C=C\[C@H]1CCC(=O)N1CCCCCCC(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
