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TargetHistamine H2 receptor
LigandBDBM50156852
Substrate/Competitorn/a
Meas. Tech.ChEMBL_429753 (CHEMBL914453)
IC50 2900±n/a nM
Citation Fonquerna, SMiralpeix, MPagès, LPuig, CCardús, AAntón, FCárdenas, AVilella, DAparici, MCalaf, EPrieto, JGras, JHuerta, JMWarrellow, GBeleta, JRyder, H Synthesis and structure-activity relationships of novel histamine H1 antagonists: indolylpiperidinyl benzoic acid derivatives. J Med Chem47:6326-37 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H2 receptor
Name:Histamine H2 receptor
Synonyms:Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_HUMAN | Histamine H2 receptor | Histamine H2-Gs alpha S
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40115.31
Organism:Homo sapiens (Human)
Description:n/a
Residue:359
Sequence:
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50156852
n/a
NameBDBM50156852
Synonyms:2-(2-(4-(1-(2-(pyridin-2-yl)ethyl)-1H-indol-3-yl)piperidin-1-yl)ethoxy)benzoic acid | CHEMBL437519
TypeSmall organic molecule
Emp. Form.C29H31N3O3
Mol. Mass.469.5747
SMILESOC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(CCc2ccccn2)c2ccccc12
Structure
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